| Title |
Role of p75 neurotrophin receptor in stem cell biology: more than just a marker
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, January 2014
|
| DOI | 10.1007/s00018-014-1564-9 |
| Pubmed ID | |
| Authors |
Elisa Tomellini, Chann Lagadec, Renata Polakowska, Xuefen Le Bourhis |
| Abstract |
p75(NTR), the common receptor for both neurotrophins and proneurotrophins, has been widely studied because of its role in many tissues, including the nervous system. More recently, a close relationship between p75(NTR) expression and pluripotency has been described. p75(NTR) was shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. Here, we give an overview of the current knowledge on p75(NTR) in stem cells, ranging from embryonic to adult stem cells, and cancer stem cells. In an attempt to address its potential role in the control of stem cell biology, the molecular mechanisms underlying p75(NTR) signaling in different models are also highlighted. p75(NTR)-mediated functions include survival, apoptosis, migration, and differentiation, and depend on cell type, (pro)neurotrophin binding, interacting transmembrane co-receptors expression, intracellular adaptor molecule availability, and post-translational modifications, such as regulated proteolytic processing. It is therefore conceivable that p75(NTR) can modulate cell-fate decisions through its highly ramified signaling pathways. Thus, elucidating the potential implications of p75(NTR) activity as well as the underlying molecular mechanisms of p75(NTR) will shed new light on the biology of both normal and cancer stem cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 107 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 20% |
| Researcher | 20 | 18% |
| Student > Master | 13 | 12% |
| Student > Bachelor | 9 | 8% |
| Student > Doctoral Student | 5 | 5% |
| Other | 16 | 15% |
| Unknown | 24 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 23% |
| Biochemistry, Genetics and Molecular Biology | 24 | 22% |
| Medicine and Dentistry | 16 | 15% |
| Neuroscience | 7 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 7 | 6% |
| Unknown | 26 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2014.
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#21,141,111
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,769
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Outputs of similar age
#270,549
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Outputs of similar age from Cellular and Molecular Life Sciences
#70
of 72 outputs
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