Title |
Emerging evidence for functional peptides encoded by short open reading frames
|
---|---|
Published in |
Nature Reviews Genetics, February 2014
|
DOI | 10.1038/nrg3520 |
Pubmed ID | |
Authors |
Shea J. Andrews, Joseph A. Rothnagel |
Abstract |
Short open reading frames (sORFs) are a common feature of all genomes, but their coding potential has mostly been disregarded, partly because of the difficulty in determining whether these sequences are translated. Recent innovations in computing, proteomics and high-throughput analyses of translation start sites have begun to address this challenge and have identified hundreds of putative coding sORFs. The translation of some of these has been confirmed, although the contribution of their peptide products to cellular functions remains largely unknown. This Review examines this hitherto overlooked component of the proteome and considers potential roles for sORF-encoded peptides. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 18% |
United Kingdom | 2 | 12% |
France | 2 | 12% |
Canada | 1 | 6% |
Japan | 1 | 6% |
Unknown | 8 | 47% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 53% |
Scientists | 7 | 41% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 12 | 2% |
Germany | 7 | <1% |
Brazil | 4 | <1% |
Netherlands | 3 | <1% |
Japan | 3 | <1% |
United Kingdom | 3 | <1% |
Canada | 2 | <1% |
Australia | 1 | <1% |
Hong Kong | 1 | <1% |
Other | 11 | 1% |
Unknown | 722 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 164 | 21% |
Researcher | 151 | 20% |
Student > Master | 93 | 12% |
Student > Bachelor | 86 | 11% |
Student > Doctoral Student | 33 | 4% |
Other | 102 | 13% |
Unknown | 140 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 275 | 36% |
Biochemistry, Genetics and Molecular Biology | 235 | 31% |
Medicine and Dentistry | 29 | 4% |
Chemistry | 17 | 2% |
Computer Science | 15 | 2% |
Other | 49 | 6% |
Unknown | 149 | 19% |