| Title |
Brain reward responses to food stimuli among female monozygotic twins discordant for BMI
|
|---|---|
| Published in |
Brain Imaging and Behavior, June 2017
|
| DOI | 10.1007/s11682-017-9711-1 |
| Pubmed ID | |
| Authors |
Stieneke Doornweerd, Eco J. De Geus, Frederik Barkhof, Liselotte Van Bloemendaal, Dorret I. Boomsma, Jenny Van Dongen, Madeleine L. Drent, Gonneke Willemsen, Dick J. Veltman, Richard G. IJzerman |
| Abstract |
Obese individuals are characterized by altered brain reward responses to food. Despite the latest discovery of obesity-associated genes, the contribution of environmental and genetic factors to brain reward responsiveness to food remains largely unclear. Sixteen female monozygotic twin pairs with a mean BMI discordance of 3.96 ± 2.1 kg/m(2) were selected from the Netherlands Twin Register to undergo functional MRI scanning while watching high- and low-calorie food and non-food pictures and during the anticipation and receipt of chocolate milk. In addition, appetite ratings, eating behavior and food intake were assessed using visual analog scales, validated questionnaires and an ad libitum lunch. In the overall group, visual and taste stimuli elicited significant activation in regions of interest (ROIs) implicated in reward, i.e. amygdala, insula, striatum and orbitofrontal cortex. However, when comparing leaner and heavier co-twins no statistically significant differences in ROI-activations were observed after family wise error correction. Heavier versus leaner co-twins reported higher feelings of hunger (P = 0.02), cravings for sweet food (P = 0.04), body dissatisfaction (P < 0.05) and a trend towards more emotional eating (P = 0.1), whereas caloric intake was not significantly different between groups (P = 0.3). Our results suggest that inherited rather than environmental factors are largely responsible for the obesity-related altered brain responsiveness to food. Future studies should elucidate the genetic variants underlying the susceptibility to reward dysfunction and obesity. NCT02025595. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 25% |
| Netherlands | 2 | 17% |
| Australia | 1 | 8% |
| Canada | 1 | 8% |
| Unknown | 5 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 58% |
| Practitioners (doctors, other healthcare professionals) | 3 | 25% |
| Scientists | 2 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 72 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 22% |
| Student > Ph. D. Student | 12 | 17% |
| Student > Bachelor | 7 | 10% |
| Student > Master | 6 | 8% |
| Student > Doctoral Student | 5 | 7% |
| Other | 9 | 13% |
| Unknown | 17 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 15 | 21% |
| Neuroscience | 8 | 11% |
| Medicine and Dentistry | 8 | 11% |
| Social Sciences | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Other | 8 | 11% |
| Unknown | 25 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2019.
All research outputs
#4,823,306
of 25,652,464 outputs
Outputs from Brain Imaging and Behavior
#244
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Outputs of similar age
#78,255
of 332,209 outputs
Outputs of similar age from Brain Imaging and Behavior
#8
of 27 outputs
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