Title |
DO IT Trial: vitamin D Outcomes and Interventions in Toddlers –a TARGet Kids! randomized controlled trial
|
---|---|
Published in |
BMC Pediatrics, February 2014
|
DOI | 10.1186/1471-2431-14-37 |
Pubmed ID | |
Authors |
Jonathon L Maguire, Catherine S Birken, Mark B Loeb, Muhammad Mamdani, Kevin Thorpe, Jeffrey S Hoch, Tony Mazzulli, Cornelia M Borkhoff, Colin Macarthur, Patricia C Parkin |
Abstract |
Vitamin D levels are alarmingly low (<75 nmol/L) in 65-70% of North American children older than 1 year. An increased risk of viral upper respiratory tract infections (URTI), asthma-related hospitalizations and use of anti-inflammatory medication have all been linked with low vitamin D. No study has determined whether wintertime vitamin D supplementation can reduce the risk of URTI and asthma exacerbations, two of the most common and costly illnesses of early childhood. The objectives of this study are: 1) to compare the effect of 'high dose' (2000 IU/day) vs. 'standard dose' (400 IU/day) vitamin D supplementation in achieving reductions in laboratory confirmed URTI and asthma exacerbations during the winter in preschool-aged Canadian children; and 2) to assess the effect of 'high dose' vitamin D supplementation on vitamin D serum levels and specific viruses that cause URTI. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 3 | 50% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
New Zealand | 1 | <1% |
Mexico | 1 | <1% |
United States | 1 | <1% |
Netherlands | 1 | <1% |
Unknown | 163 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 26 | 16% |
Student > Master | 23 | 14% |
Other | 14 | 8% |
Researcher | 13 | 8% |
Student > Postgraduate | 12 | 7% |
Other | 37 | 22% |
Unknown | 42 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 54 | 32% |
Nursing and Health Professions | 18 | 11% |
Agricultural and Biological Sciences | 11 | 7% |
Biochemistry, Genetics and Molecular Biology | 8 | 5% |
Psychology | 4 | 2% |
Other | 19 | 11% |
Unknown | 53 | 32% |