| Title |
Low serum diamine oxidase (DAO) activity levels in patients with migraine
|
|---|---|
| Published in |
Journal of Physiology and Biochemistry, June 2017
|
| DOI | 10.1007/s13105-017-0571-3 |
| Pubmed ID | |
| Authors |
Joan Izquierdo-Casas, Oriol Comas-Basté, M. Luz Latorre-Moratalla, Marian Lorente-Gascón, Adriana Duelo, M. Carmen Vidal-Carou, Luis Soler-Singla |
| Abstract |
Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by a deficiency in the enzyme diamine oxidase (DAO). Among the several multi-faced symptoms associated with histamine intolerance, headache is one of the most recognized and disabling consequences. The aim of this study was to determine the prevalence of DAO deficiency in patients with a confirmed migraine diagnosis according to the current International Headache Society (IHS) and in non-migraine subjects. DAO activity was assessed in a total of 198 volunteers recruited at the Headache Unit of the Hospital General de Catalunya, 137 in the migraine group and 61 as a control group. DAO enzyme activity in blood samples was determined by ELISA test. Values below 80 HDU/ml (Histamine Degrading Unit/ml) were considered as DAO deficient. Mean value of DAO activity from migraine population (64.5 ± 33.5 HDU/ml) was significantly lower (p < 0.0001) than that obtained from healthy volunteers (91.9 ± 44.3 HDU/ml). DAO deficiency was more prevalent in migraine patients than in the control group. A high incidence rate of DAO deficiency (87%) was observed in the group of patients with migraine. On the other hand, 44% of non-migranous subjects had levels of DAO activity lower than 80 HDU/ml. Despite the multifactorial aetiology of migraine, these results seem to indicate that this enzymatic deficit could be related to the onset of migraine. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 7 | 25% |
| United States | 5 | 18% |
| Netherlands | 1 | 4% |
| Mexico | 1 | 4% |
| Belgium | 1 | 4% |
| Unknown | 13 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 86% |
| Scientists | 2 | 7% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 1% |
| Unknown | 92 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 15% |
| Student > Bachelor | 14 | 15% |
| Other | 11 | 12% |
| Student > Ph. D. Student | 8 | 9% |
| Researcher | 6 | 6% |
| Other | 15 | 16% |
| Unknown | 25 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 22% |
| Nursing and Health Professions | 13 | 14% |
| Biochemistry, Genetics and Molecular Biology | 12 | 13% |
| Agricultural and Biological Sciences | 4 | 4% |
| Immunology and Microbiology | 3 | 3% |
| Other | 12 | 13% |
| Unknown | 29 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 99. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2023.
All research outputs
#432,483
of 25,649,244 outputs
Outputs from Journal of Physiology and Biochemistry
#3
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Outputs of similar age
#9,086
of 331,166 outputs
Outputs of similar age from Journal of Physiology and Biochemistry
#1
of 10 outputs
Altmetric has tracked 25,649,244 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 619 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done particularly well, scoring higher than 99% of its peers.
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