| Title |
The Microbiome and Psoriatic Arthritis
|
|---|---|
| Published in |
Current Rheumatology Reports, January 2014
|
| DOI | 10.1007/s11926-013-0407-2 |
| Pubmed ID | |
| Authors |
Hester Eppinga, Sergey R. Konstantinov, Maikel P. Peppelenbosch, H. Bing Thio |
| Abstract |
Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce inflammatory disease in individuals with underlying genetic susceptibility. The microbiome is a subject of increasing interest in the etiology of these inflammatory immune-mediated diseases. The intestinal microbiome is able to affect extra-intestinal distant sites, including the joints, through immunomodulation. At this point, evidence regarding a relationship between the microbiome and psoriatic arthritis is scarce. However, we hypothesize that common immune-mediated inflammatory pathways seen in the "skin-joint-gut axis" in psoriatic arthritis are induced or at least mediated by the microbiome. Th17 has a crucial function in this mechanism. Further establishment of this connection may lead to novel therapeutic approaches for psoriatic arthritis. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| India | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 18% |
| Researcher | 8 | 16% |
| Student > Bachelor | 6 | 12% |
| Student > Postgraduate | 3 | 6% |
| Student > Ph. D. Student | 3 | 6% |
| Other | 4 | 8% |
| Unknown | 16 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 20% |
| Agricultural and Biological Sciences | 6 | 12% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Immunology and Microbiology | 5 | 10% |
| Nursing and Health Professions | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 19 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2017.
All research outputs
#12,700,323
of 22,743,667 outputs
Outputs from Current Rheumatology Reports
#394
of 709 outputs
Outputs of similar age
#154,046
of 308,149 outputs
Outputs of similar age from Current Rheumatology Reports
#6
of 13 outputs
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