| Title |
Behaviour of intrinsically disordered proteins in protein–protein complexes with an emphasis on fuzziness
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, June 2017
|
| DOI | 10.1007/s00018-017-2560-7 |
| Pubmed ID | |
| Authors |
Johan G. Olsen, Kaare Teilum, Birthe B. Kragelund |
| Abstract |
Intrinsically disordered proteins (IDPs) do not, by themselves, fold into a compact globular structure. They are extremely dynamic and flexible, and are typically involved in signalling and transduction of information through binding to other macromolecules. The reason for their existence may lie in their malleability, which enables them to bind several different partners with high specificity. In addition, their interactions with other macromolecules can be regulated by a variable amount of chemically diverse post-translational modifications. Four kinetically and energetically different types of complexes between an IDP and another macromolecule are reviewed: (1) simple two-state binding involving a single binding site, (2) avidity, (3) allovalency and (4) fuzzy binding; the last three involving more than one site. Finally, a qualitative definition of fuzzy binding is suggested, examples are provided, and its distinction to allovalency and avidity is highlighted and discussed. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 171 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 20% |
| Student > Master | 25 | 15% |
| Researcher | 24 | 14% |
| Student > Bachelor | 24 | 14% |
| Other | 8 | 5% |
| Other | 22 | 13% |
| Unknown | 34 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 73 | 43% |
| Agricultural and Biological Sciences | 25 | 15% |
| Chemistry | 20 | 12% |
| Physics and Astronomy | 3 | 2% |
| Engineering | 2 | 1% |
| Other | 9 | 5% |
| Unknown | 39 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2021.
All research outputs
#16,031,680
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,071
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Outputs of similar age
#201,204
of 318,615 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#29
of 54 outputs
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