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Variability of oxidative stress biomarkers in hemodialysis patients

Overview of attention for article published in Biomarkers, February 2014
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Title
Variability of oxidative stress biomarkers in hemodialysis patients
Published in
Biomarkers, February 2014
DOI 10.3109/1354750x.2013.867533
Pubmed ID
Authors

Rumbidzai Dahwa, Robert G. Fassett, Zaimin Wang, David Briskey, Alistair R. Mallard, Jeff S. Coombes

Abstract

Oxidative stress biomarkers may have a role in the future to assist clinical decisions regarding the use of antioxidant therapies and their efficacy. The aims of this study were to evaluate the within and between-individual variability of plasma oxidative stress biomarkers and investigate factors affecting their variability. Plasma F2-isoprostanes and protein carbonyls were measured in 14 hemodialysis patients every 2 weeks for 10 weeks. Within-individual coefficients of variation (CVs) were isoprostanes = 30.4% (range = 6.1-66.7%) and protein carbonyls = 16.3% (8.4-29.5%). Between-individual CVs were isoprostanes = 34.4% (28.9-40.2%) and protein carbonyls = 19.5% (15.6-24.5%). There were no significant (p > 0.05) relationships between the oxidative stress biomarkers and dietary antioxidant intake, medications, clinical and demographic parameters.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 23%
Student > Postgraduate 4 18%
Student > Bachelor 2 9%
Researcher 2 9%
Student > Doctoral Student 1 5%
Other 4 18%
Unknown 4 18%
Readers by discipline Count As %
Medicine and Dentistry 7 32%
Biochemistry, Genetics and Molecular Biology 3 14%
Agricultural and Biological Sciences 3 14%
Immunology and Microbiology 2 9%
Psychology 1 5%
Other 1 5%
Unknown 5 23%