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High sensitivity non‐invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy

Overview of attention for article published in Journal of Biophotonics, June 2017
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  • Good Attention Score compared to outputs of the same age and source (71st percentile)

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Title
High sensitivity non‐invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy
Published in
Journal of Biophotonics, June 2017
DOI 10.1002/jbio.201600260
Pubmed ID
Authors

Adrian Ghita, Pavel Matousek, Nick Stone

Abstract

The aim of this research was to develop a novel approach to probe non-invasively the composition of inorganic chemicals buried deep in large volume biological samples. The method is based on advanced Transmission Raman Spectroscopy (TRS) permitting chemical specific detection within a large sampling volume. The approach could be beneficial to chemical identification of the breast calcifications detected during mammographic X-ray procedures. The chemical composition of a breast calcification reflects the pathology of the surrounding tissue, malignant or benign and potentially the grade of malignancy. However, this information is not available from mammography, leading to excisional biopsy and histopathological assessment for a definitive diagnosis. Here we present, for the first time, a design of a new high performance deep Raman instrument and demonstrate its capability to detect type II calcifications (calcium hydroxyapatite) at clinically relevant concentrations and depths of around 40 mm in phantom tissue. This is around double the penetration depth achieved with our previous instrument design and around two orders of magnitude higher than that possible when using conventional Raman spectroscopy.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 51 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 20%
Researcher 8 16%
Student > Master 5 10%
Student > Bachelor 4 8%
Other 3 6%
Other 5 10%
Unknown 16 31%
Readers by discipline Count As %
Engineering 8 16%
Chemistry 7 14%
Biochemistry, Genetics and Molecular Biology 4 8%
Medicine and Dentistry 4 8%
Physics and Astronomy 4 8%
Other 3 6%
Unknown 21 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2019.
All research outputs
#14,363,681
of 24,520,935 outputs
Outputs from Journal of Biophotonics
#604
of 2,307 outputs
Outputs of similar age
#161,266
of 321,181 outputs
Outputs of similar age from Journal of Biophotonics
#11
of 38 outputs
Altmetric has tracked 24,520,935 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,307 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,181 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.