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The spliceosome: disorder and dynamics defined

Overview of attention for article published in Current Opinion in Structural Biology, February 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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2 X users
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2 patents

Citations

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72 Dimensions

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130 Mendeley
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Title
The spliceosome: disorder and dynamics defined
Published in
Current Opinion in Structural Biology, February 2014
DOI 10.1016/j.sbi.2014.01.009
Pubmed ID
Authors

Weijun Chen, Melissa J Moore

Abstract

Among the many macromolecular machines involved in eukaryotic gene expression, the spliceosome remains one of the most challenging for structural biologists. Defining features of this highly complex apparatus are its excessive number of individual parts, many of which have been evolutionarily selected for regions of structural disorder, and the remarkable compositional and conformation dynamics it must undertake to complete each round of splicing. Here we review recent advances in our understanding of spliceosome structural dynamics stemming from bioinformatics, deep sequencing, high throughput methods for determining protein-protein, protein-RNA and RNA-RNA interaction dynamics, single molecule microscopy and more traditional structural analyses. Together, these tools are rapidly changing our structural appreciation of this remarkably dynamic machine.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 <1%
Unknown 129 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 30%
Researcher 33 25%
Student > Master 20 15%
Professor > Associate Professor 6 5%
Student > Doctoral Student 4 3%
Other 7 5%
Unknown 21 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 61 47%
Biochemistry, Genetics and Molecular Biology 26 20%
Chemistry 4 3%
Immunology and Microbiology 3 2%
Medicine and Dentistry 3 2%
Other 6 5%
Unknown 27 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2016.
All research outputs
#5,165,888
of 25,373,627 outputs
Outputs from Current Opinion in Structural Biology
#515
of 2,067 outputs
Outputs of similar age
#59,649
of 330,518 outputs
Outputs of similar age from Current Opinion in Structural Biology
#6
of 15 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,067 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,518 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.