| Title |
Hypoxia and Bone Metastatic Disease
|
|---|---|
| Published in |
Current Osteoporosis Reports, June 2017
|
| DOI | 10.1007/s11914-017-0378-8 |
| Pubmed ID | |
| Authors |
Rachelle W. Johnson, Miranda E. Sowder, Amato J. Giaccia |
| Abstract |
This review highlights our current knowledge of oxygen tensions in the bone marrow, and how low oxygen tensions (hypoxia) regulate tumor metastasis to and colonization of the bone marrow. The bone marrow is a relatively hypoxic microenvironment, but oxygen tensions fluctuate throughout the marrow cavity and across the endosteal and periosteal surfaces. Recent advances in imaging have made it possible to better characterize these fluctuations in bone oxygenation, but technical challenges remain. We have compiled evidence from multiple groups that suggests that hypoxia or hypoxia inducible factor (HIF) signaling may induce spontaneous metastasis to the bone and promote tumor colonization of bone, particularly in the case of breast cancer dissemination to the bone marrow. We are beginning to understand oxygenation patterns within the bone compartment and the role for hypoxia and HIF signaling in tumor cell dissemination to the bone marrow, but further studies are warranted. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 87 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 21% |
| Student > Bachelor | 14 | 16% |
| Researcher | 12 | 14% |
| Student > Doctoral Student | 6 | 7% |
| Student > Master | 6 | 7% |
| Other | 8 | 9% |
| Unknown | 23 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 23% |
| Medicine and Dentistry | 11 | 13% |
| Engineering | 7 | 8% |
| Agricultural and Biological Sciences | 6 | 7% |
| Chemistry | 3 | 3% |
| Other | 12 | 14% |
| Unknown | 28 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2017.
All research outputs
#20,428,633
of 22,981,247 outputs
Outputs from Current Osteoporosis Reports
#473
of 549 outputs
Outputs of similar age
#276,061
of 317,339 outputs
Outputs of similar age from Current Osteoporosis Reports
#19
of 23 outputs
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