Title |
IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets
|
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Published in |
Diabetologia, December 2013
|
DOI | 10.1007/s00125-013-3135-2 |
Pubmed ID | |
Authors |
Fabio A. Grieco, Fabrice Moore, François Vigneron, Izortze Santin, Olatz Villate, Lorella Marselli, Dieter Rondas, Hannelie Korf, Lutgart Overbergh, Francesco Dotta, Piero Marchetti, Chantal Mathieu, Décio L. Eizirik |
Abstract |
Cytotoxic T cells and macrophages contribute to beta cell destruction in type 1 diabetes at least in part through the production of cytokines such as IL-1β, IFN-γ and TNF-α. We have recently shown the IL-17 pathway to be activated in circulating T cells and pancreatic islets of type 1 diabetes patients. Here, we studied whether IL-17A upregulates the production of chemokines by human pancreatic islets, thus contributing to the build-up of insulitis. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 63 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 33% |
Student > Master | 11 | 17% |
Professor | 6 | 9% |
Other | 6 | 9% |
Student > Ph. D. Student | 5 | 8% |
Other | 11 | 17% |
Unknown | 4 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 27% |
Agricultural and Biological Sciences | 16 | 25% |
Medicine and Dentistry | 15 | 23% |
Immunology and Microbiology | 4 | 6% |
Veterinary Science and Veterinary Medicine | 3 | 5% |
Other | 4 | 6% |
Unknown | 5 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2015.
All research outputs
#13,901,936
of 23,577,654 outputs
Outputs from Diabetologia
#4,330
of 5,140 outputs
Outputs of similar age
#169,031
of 310,144 outputs
Outputs of similar age from Diabetologia
#25
of 49 outputs
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