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EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression

Overview of attention for article published in Molecular Cancer, January 2017
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Title
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
Published in
Molecular Cancer, January 2017
DOI 10.1186/s12943-016-0579-2
Pubmed ID
Authors

Davide Pradella, Chiara Naro, Claudio Sette, Claudia Ghigna

Abstract

Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well as with generation and maintenance of cancer stem cells. In this way, EMT contributes to tumor invasion, heterogeneity and chemoresistance. Morphological and functional changes involved in these processes require robust reprogramming of gene expression, which is only partially accomplished at the transcriptional level. Alternative splicing is another essential layer of gene expression regulation that expands the cell proteome. This step in post-transcriptional regulation of gene expression tightly controls cell identity between epithelial and mesenchymal states and during stem cell differentiation. Importantly, dysregulation of splicing factor function and cancer-specific splicing isoform expression frequently occurs in human tumors, suggesting the importance of alternative splicing regulation for cancer biology.In this review, we briefly discuss the role of EMT programs in development, stem cell differentiation and cancer progression. Next, we focus on selected examples of key factors involved in EMT and stem cell differentiation that are regulated post-transcriptionally through alternative splicing mechanisms. Lastly, we describe relevant oncogenic splice-variants that directly orchestrate cancer stem cell biology and tumor EMT, which may be envisioned as novel targets for therapeutic intervention.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 233 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 232 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 57 24%
Researcher 28 12%
Student > Master 26 11%
Student > Bachelor 22 9%
Student > Postgraduate 17 7%
Other 35 15%
Unknown 48 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 95 41%
Agricultural and Biological Sciences 39 17%
Medicine and Dentistry 22 9%
Chemistry 4 2%
Unspecified 3 1%
Other 17 7%
Unknown 53 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2017.
All research outputs
#18,556,449
of 22,982,639 outputs
Outputs from Molecular Cancer
#1,297
of 1,731 outputs
Outputs of similar age
#310,652
of 420,173 outputs
Outputs of similar age from Molecular Cancer
#32
of 43 outputs
Altmetric has tracked 22,982,639 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,731 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,173 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.