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Serum biomarkers can predict a change in liver fibrosis 1 year after lifestyle intervention for biopsy‐proven NASH

Overview of attention for article published in Liver International, June 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

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1 news outlet
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Title
Serum biomarkers can predict a change in liver fibrosis 1 year after lifestyle intervention for biopsy‐proven NASH
Published in
Liver International, June 2017
DOI 10.1111/liv.13480
Pubmed ID
Authors

Eduardo Vilar‐Gomez, Luis Calzadilla‐Bertot, Scott L. Friedman, Bienvenido Gra‐Oramas, Licet Gonzalez‐Fabian, Sacha Lazo‐del Vallin, Moises Diago, Leon A. Adams

Abstract

The dynamic response of serum fibrosis biomarkers to histological changes within the liver following lifestyle intervention (LI) is unknown. We explored relationships between changes in serum biomarkers and liver fibrosis in NASH patients undergoing LI. Paired liver biopsies were performed in 261 NASH patients to assess fibrosis change after 1 year of LI. We explored the utility of serum fibrosis markers to predict changes in hepatic fibrosis and developed and internally validated a model for predicting fibrosis improvement in patients with baseline fibrosis. Regression, stabilization and worsening of fibrosis occurred in 51 (20%), 165 (63%) and 45 (17%) patients, respectively. By multivariable analysis, change in HbA1c (OR, 0.39, P<0.01), platelets (OR, 1.22, P<.01), and NFS (OR, 0.27, P<.01), as well as ALT normalization (OR, 9.7, P<.01), were independently associated with fibrosis improvement, whereas change in platelets (OR, 0.96, P<.01), and NFS (OR 1.8, P<.01) as well as ALT normalization (OR, 0.21, P<.01) were linked to fibrosis progression. A model, including change in HbA1c, platelet and ALT normalization, was significantly more accurate (AUC of 0.96, 95% CI:0.94-0.99) than NFS, FIB-4, and APRI for predicting fibrosis improvement. Using a threshold of ≥0.497, positive and negative predictive values were 94% (95% CI:84-98) and 91% (95% CI:81-96), respectively. Change in NFS, platelets and ALT normalization are associated with change in liver fibrosis after 1 year of LI. A model including change in HbA1c, platelet and ALT normalization discriminated patients with fibrosis improvement significantly better than other biomarkers. This article is protected by copyright. All rights reserved.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 19%
Other 7 15%
Student > Master 5 11%
Student > Ph. D. Student 3 6%
Student > Doctoral Student 2 4%
Other 6 13%
Unknown 15 32%
Readers by discipline Count As %
Medicine and Dentistry 17 36%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Engineering 2 4%
Agricultural and Biological Sciences 2 4%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 3 6%
Unknown 20 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2019.
All research outputs
#3,530,095
of 24,477,448 outputs
Outputs from Liver International
#322
of 2,882 outputs
Outputs of similar age
#63,055
of 321,736 outputs
Outputs of similar age from Liver International
#1
of 39 outputs
Altmetric has tracked 24,477,448 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,882 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,736 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.