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Multimodal Polymer Nanoparticles with Combined 19F Magnetic Resonance and Optical Detection for Tunable, Targeted, Multimodal Imaging in Vivo

Overview of attention for article published in Journal of the American Chemical Society, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

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7 X users
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12 patents

Citations

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156 Dimensions

Readers on

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129 Mendeley
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Title
Multimodal Polymer Nanoparticles with Combined 19F Magnetic Resonance and Optical Detection for Tunable, Targeted, Multimodal Imaging in Vivo
Published in
Journal of the American Chemical Society, January 2014
DOI 10.1021/ja410351h
Pubmed ID
Authors

Barbara E. Rolfe, Idriss Blakey, Oliver Squires, Hui Peng, Nathan R. B. Boase, Cameron Alexander, Peter G. Parsons, Glen M. Boyle, Andrew K. Whittaker, Kristofer J. Thurecht

Abstract

Understanding the complex nature of diseased tissue in vivo requires development of more advanced nanomedicines, where synthesis of multifunctional polymers combines imaging multimodality with a biocompatible, tunable, and functional nanomaterial carrier. Here we describe the development of polymeric nanoparticles for multimodal imaging of disease states in vivo. The nanoparticle design utilizes the abundant functionality and tunable physicochemical properties of synthetically robust polymeric systems to facilitate targeted imaging of tumors in mice. For the first time, high-resolution (19)F/(1)H magnetic resonance imaging is combined with sensitive and versatile fluorescence imaging in a polymeric material for in vivo detection of tumors. We highlight how control over the chemistry during synthesis allows manipulation of nanoparticle size and function and can lead to very high targeting efficiency to B16 melanoma cells, both in vitro and in vivo. Importantly, the combination of imaging modalities within a polymeric nanoparticle provides information on the tumor mass across various size scales in vivo, from millimeters down to tens of micrometers.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 2 2%
United States 1 <1%
India 1 <1%
Germany 1 <1%
Unknown 124 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 27%
Researcher 24 19%
Student > Master 15 12%
Student > Bachelor 12 9%
Student > Doctoral Student 11 9%
Other 19 15%
Unknown 13 10%
Readers by discipline Count As %
Chemistry 57 44%
Engineering 9 7%
Medicine and Dentistry 8 6%
Physics and Astronomy 7 5%
Biochemistry, Genetics and Molecular Biology 7 5%
Other 21 16%
Unknown 20 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2024.
All research outputs
#3,354,900
of 25,481,734 outputs
Outputs from Journal of the American Chemical Society
#10,108
of 66,716 outputs
Outputs of similar age
#38,267
of 323,835 outputs
Outputs of similar age from Journal of the American Chemical Society
#95
of 528 outputs
Altmetric has tracked 25,481,734 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 66,716 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,835 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 528 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.