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Spread, Circulation, and Evolution of the Middle East Respiratory Syndrome Coronavirus

Overview of attention for article published in mBio, February 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

blogs
2 blogs
policy
2 policy sources
twitter
30 X users
patent
8 patents
wikipedia
2 Wikipedia pages
googleplus
1 Google+ user

Citations

dimensions_citation
234 Dimensions

Readers on

mendeley
257 Mendeley
citeulike
3 CiteULike
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Title
Spread, Circulation, and Evolution of the Middle East Respiratory Syndrome Coronavirus
Published in
mBio, February 2014
DOI 10.1128/mbio.01062-13
Pubmed ID
Authors

Matthew Cotten, Simon J. Watson, Alimuddin I. Zumla, Hatem Q. Makhdoom, Anne L. Palser, Swee Hoe Ong, Abdullah A. Al Rabeeah, Rafat F. Alhakeem, Abdullah Assiri, Jaffar A. Al-Tawfiq, Ali Albarrak, Mazin Barry, Atef Shibl, Fahad A. Alrabiah, Sami Hajjar, Hanan H. Balkhy, Hesham Flemban, Andrew Rambaut, Paul Kellam, Ziad A. Memish

Abstract

The Middle East respiratory syndrome coronavirus (MERS-CoV) was first documented in the Kingdom of Saudi Arabia (KSA) in 2012 and, to date, has been identified in 180 cases with 43% mortality. In this study, we have determined the MERS-CoV evolutionary rate, documented genetic variants of the virus and their distribution throughout the Arabian peninsula, and identified the genome positions under positive selection, important features for monitoring adaptation of MERS-CoV to human transmission and for identifying the source of infections. Respiratory samples from confirmed KSA MERS cases from May to September 2013 were subjected to whole-genome deep sequencing, and 32 complete or partial sequences (20 were ≥ 99% complete, 7 were 50 to 94% complete, and 5 were 27 to 50% complete) were obtained, bringing the total available MERS-CoV genomic sequences to 65. An evolutionary rate of 1.12 × 10(-3) substitutions per site per year (95% credible interval [95% CI], 8.76 × 10(-4); 1.37 × 10(-3)) was estimated, bringing the time to most recent common ancestor to March 2012 (95% CI, December 2011; June 2012). Only one MERS-CoV codon, spike 1020, located in a domain required for cell entry, is under strong positive selection. Four KSA MERS-CoV phylogenetic clades were found, with 3 clades apparently no longer contributing to current cases. The size of the population infected with MERS-CoV showed a gradual increase to June 2013, followed by a decline, possibly due to increased surveillance and infection control measures combined with a basic reproduction number (R0) for the virus that is less than 1.

X Demographics

X Demographics

The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 257 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
Netherlands 1 <1%
Korea, Republic of 1 <1%
Italy 1 <1%
Canada 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 249 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 46 18%
Student > Master 40 16%
Student > Ph. D. Student 39 15%
Student > Bachelor 29 11%
Other 17 7%
Other 42 16%
Unknown 44 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 57 22%
Medicine and Dentistry 42 16%
Biochemistry, Genetics and Molecular Biology 32 12%
Immunology and Microbiology 19 7%
Veterinary Science and Veterinary Medicine 10 4%
Other 45 18%
Unknown 52 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 51. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2023.
All research outputs
#829,498
of 25,537,395 outputs
Outputs from mBio
#613
of 6,556 outputs
Outputs of similar age
#7,951
of 239,141 outputs
Outputs of similar age from mBio
#14
of 63 outputs
Altmetric has tracked 25,537,395 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,556 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,141 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.