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High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory

Overview of attention for article published in Neurobiology of Aging, June 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#13 of 4,418)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
37 news outlets
blogs
2 blogs
twitter
47 X users
facebook
1 Facebook page

Citations

dimensions_citation
142 Dimensions

Readers on

mendeley
258 Mendeley
citeulike
1 CiteULike
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Title
High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory
Published in
Neurobiology of Aging, June 2017
DOI 10.1016/j.neurobiolaging.2017.06.014
Pubmed ID
Authors

Sarah J. Spencer, Heather D'Angelo, Alita Soch, Linda R. Watkins, Steven F. Maier, Ruth M. Barrientos

Abstract

More Americans are consuming diets higher in saturated fats and refined sugars than ever before, and based on increasing obesity rates, this is a growing trend among older adults as well. While high saturated fat diet (HFD) consumption has been shown to sensitize the inflammatory response to a subsequent immune challenge in young adult rats, the inflammatory effect of HFD in the already-vulnerable aging brain has not yet been assessed. Here, we explored whether short-term (3 days) consumption of HFD would serve as a neuroinflammatory trigger in aging animals, leading to cognitive deficits. HFD impaired long-term contextual (hippocampal dependent) and auditory-cued fear (amygdalar dependent) memory in aged, but not young adult rats. Short-term memory performance for both tasks was intact, suggesting that HFD impairs memory consolidation processes. Microglial markers of activation Iba1 and cd11b were only increased in the aged rats, while MHCII was further amplified by HFD. Furthermore, these HFD-induced long-term memory impairments were accompanied by IL-1β protein increases in both the hippocampus and amygdala in aged rats. Central administration of IL-1RA in aged rats following conditioning mitigated both contextual and auditory-cued fear memory impairments caused by HFD, strongly suggesting that IL-1β plays a critical role in these effects. Voluntary wheel running, known to have anti-inflammatory effects in the hippocampus, rescued hippocampal-dependent but not amygdalar-dependent memory impairments caused by HFD. Together, these data suggest that short-term consumption of HFD can lead to memory deficits and significant brain inflammation in the aged animal, and strongly suggest that appropriate diet is crucial for cognitive health.

X Demographics

X Demographics

The data shown below were collected from the profiles of 47 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 258 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 258 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 47 18%
Student > Master 33 13%
Student > Bachelor 19 7%
Researcher 17 7%
Student > Doctoral Student 17 7%
Other 40 16%
Unknown 85 33%
Readers by discipline Count As %
Neuroscience 49 19%
Agricultural and Biological Sciences 26 10%
Medicine and Dentistry 17 7%
Biochemistry, Genetics and Molecular Biology 14 5%
Psychology 9 3%
Other 41 16%
Unknown 102 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 300. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2023.
All research outputs
#115,571
of 25,382,440 outputs
Outputs from Neurobiology of Aging
#13
of 4,418 outputs
Outputs of similar age
#2,548
of 329,052 outputs
Outputs of similar age from Neurobiology of Aging
#2
of 75 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,418 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,052 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.