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Human papillomavirus (HPV) genotypes in an Australian sample of anal cancers

Overview of attention for article published in International Journal of Cancer, February 2014
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Title
Human papillomavirus (HPV) genotypes in an Australian sample of anal cancers
Published in
International Journal of Cancer, February 2014
DOI 10.1002/ijc.28730
Pubmed ID
Authors

Richard J. Hillman, Suzanne M. Garland, Manoji P.W. Gunathilake, Matthew Stevens, Nirmala Kumaradevan, Charlotte Lemech, Robyn L. Ward, Alan Meagher, Leo McHugh, Fengyi Jin, Susan Carroll, David Goldstein, Andrew E. Grulich, Sepehr N. Tabrizi

Abstract

Human papillomavirus (HPV) causes most cases of anal cancers. In this study, we analyzed biopsy material from 112 patients with anal cancers in Australia for the presence of HPV DNA by the INNO LiPA HPV genotyping assay. There were 82% (92) males and 18% (20) females. The mean age at diagnosis was significantly (p = 0.006) younger for males (52.5 years) than females (66 years). HIV-infected males were diagnosed at a much earlier mean age (48.2 years) than HIV negative (56.3 years) males (p = 0.05). HPV DNA was detected in 96.4% (108) of cases. HPV type 16 was the commonest, at 75% (81) of samples and being the sole genotype detected in 61% (66). Overall, 79% (85) of cases had at least one genotype targeted by the bivalent HPV (bHPV) vaccine, 90% (97) by the quadrivalent HPV (qHPV) vaccine and 96% (104) by the nonavalent HPV (nHPV) vaccine. The qHPV vaccine, which is now offered to all secondary school students in Australia, may prevent anal cancers in Australia. However, given the mean age of onset of this condition, the vaccine is unlikely to have a significant impact for several decades. Further research is necessary to prove additional protective effects of the nHPV vaccine.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
United States 1 2%
Unknown 58 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 13%
Student > Master 8 13%
Student > Doctoral Student 5 8%
Student > Bachelor 5 8%
Student > Ph. D. Student 5 8%
Other 13 21%
Unknown 17 28%
Readers by discipline Count As %
Medicine and Dentistry 21 34%
Social Sciences 4 7%
Agricultural and Biological Sciences 4 7%
Biochemistry, Genetics and Molecular Biology 3 5%
Computer Science 2 3%
Other 9 15%
Unknown 18 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2015.
All research outputs
#16,707,477
of 24,571,708 outputs
Outputs from International Journal of Cancer
#10,029
of 12,088 outputs
Outputs of similar age
#200,005
of 318,012 outputs
Outputs of similar age from International Journal of Cancer
#81
of 108 outputs
Altmetric has tracked 24,571,708 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,088 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,012 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.