| Title |
Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells
|
|---|---|
| Published in |
BMC Cancer, February 2011
|
| DOI | 10.1186/1471-2407-11-81 |
| Pubmed ID | |
| Authors |
Wataru Habano, Toshie Gamo, Jun Terashima, Tamotsu Sugai, Koki Otsuka, Go Wakabayashi, Shogo Ozawa |
| Abstract |
Pregnane X receptor (PXR) is a key transcription factor that regulates drug metabolizing enzymes such as cytochrome P450 (CYP) 3A4, and plays important roles in intestinal first-pass metabolism. Although there is a large inter-individual heterogeneity with intestinal CYP3A4 expression and activity, the mechanism driving these differences is not sufficiently explained by genetic variability of PXR or CYP3A4. We examined whether epigenetic mechanisms are involved in the regulation of PXR/CYP3A4 pathways in colon cancer cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Denmark | 1 | 2% |
| Unknown | 57 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 22% |
| Researcher | 12 | 20% |
| Student > Master | 11 | 19% |
| Student > Postgraduate | 5 | 8% |
| Student > Doctoral Student | 4 | 7% |
| Other | 8 | 14% |
| Unknown | 6 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 29% |
| Medicine and Dentistry | 15 | 25% |
| Biochemistry, Genetics and Molecular Biology | 10 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
| Computer Science | 2 | 3% |
| Other | 4 | 7% |
| Unknown | 7 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2014.
All research outputs
#18,365,132
of 22,745,803 outputs
Outputs from BMC Cancer
#5,419
of 8,272 outputs
Outputs of similar age
#94,157
of 106,769 outputs
Outputs of similar age from BMC Cancer
#28
of 32 outputs
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