Title |
Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity
|
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Published in |
Biological Psychiatry, September 2013
|
DOI | 10.1016/j.biopsych.2013.07.038 |
Pubmed ID | |
Authors |
Veronica B. Perez, Scott W. Woods, Brian J. Roach, Judith M. Ford, Thomas H. McGlashan, Vinod H. Srihari, Daniel H. Mathalon |
Abstract |
Only about one third of patients at high risk for psychosis based on current clinical criteria convert to a psychotic disorder within a 2.5-year follow-up period. Targeting clinical high-risk (CHR) individuals for preventive interventions could expose many to unnecessary treatments, underscoring the need to enhance predictive accuracy with nonclinical measures. Candidate measures include event-related potential components with established sensitivity to schizophrenia. Here, we examined the mismatch negativity (MMN) component of the event-related potential elicited automatically by auditory deviance in CHR and early illness schizophrenia (ESZ) patients. We also examined whether MMN predicted subsequent conversion to psychosis in CHR patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 25% |
Chile | 1 | 13% |
Egypt | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
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Members of the public | 6 | 75% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 5 | 3% |
Canada | 1 | <1% |
Unknown | 158 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 39 | 24% |
Researcher | 33 | 20% |
Student > Master | 19 | 12% |
Other | 16 | 10% |
Student > Bachelor | 12 | 7% |
Other | 26 | 16% |
Unknown | 19 | 12% |
Readers by discipline | Count | As % |
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Psychology | 37 | 23% |
Neuroscience | 36 | 22% |
Medicine and Dentistry | 33 | 20% |
Agricultural and Biological Sciences | 6 | 4% |
Biochemistry, Genetics and Molecular Biology | 3 | 2% |
Other | 11 | 7% |
Unknown | 38 | 23% |