| Title |
Neural Stem Cell Transplants Improve Cognitive Function Without Altering Amyloid Pathology in an APP/PS1 Double Transgenic Model of Alzheimer’s Disease
|
|---|---|
| Published in |
Molecular Neurobiology, January 2014
|
| DOI | 10.1007/s12035-014-8640-x |
| Pubmed ID | |
| Authors |
Wei Zhang, Pei-Jun Wang, Hong-ying Sha, Jiong Ni, Ming-hua Li, Guo-jun Gu |
| Abstract |
Neural stem cells (NSCs) are capable of self-renewal and are multipotent. Transplantation of NSCs may represent a promising approach for treating neurodegenerative disorders associated with cognitive decline, such as Alzheimer disease (AD) characterized by extensive loss of neurons. In this study, we investigated the effect of NSC transplantation on cognitive function in the amyloid precursor protein/presenilin-1 (APP/PS1) transgenic mouse, an AD mouse model with age-dependent cognitive deficits. We found that NSCs bilaterally transplanted into hippocampal regions improved spatial learning and memory function in these mice, but did not alter Aβ pathology. Immunohistochemical analyses determined that NSCs proliferated, migrated, and differentiated into three neuronal cell types. The improvement in cognitive function was correlated with enhanced long-term potentiation (LTP) and an increase in the neuron expression of proteins related to cognitive function: N-methyl-D-aspartate (NMDA) 2B unit, synaptophysin (SYP), protein kinase C ζ subtypes (PKCζ), tyrosine receptor kinase B (TrkB), and brain-derived neurotrophic factor (BDNF). Taken together, our data indicated that injected NSCs can rescue cognitive deficits in APP/PS1 transgenic mice by replacing neuronal cell types expressing multiple cognition-related proteins that enhance LTP. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 2% |
| Unknown | 64 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 12 | 18% |
| Student > Master | 11 | 17% |
| Student > Ph. D. Student | 8 | 12% |
| Researcher | 7 | 11% |
| Student > Doctoral Student | 6 | 9% |
| Other | 7 | 11% |
| Unknown | 14 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 15 | 23% |
| Agricultural and Biological Sciences | 13 | 20% |
| Medicine and Dentistry | 9 | 14% |
| Biochemistry, Genetics and Molecular Biology | 8 | 12% |
| Nursing and Health Professions | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 14 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2014.
All research outputs
#15,294,762
of 22,745,803 outputs
Outputs from Molecular Neurobiology
#2,043
of 3,434 outputs
Outputs of similar age
#189,453
of 306,973 outputs
Outputs of similar age from Molecular Neurobiology
#6
of 24 outputs
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