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Attention Score in Context
| Title |
NFIB-Mediated Repression of the Epigenetic Factor Ezh2 Regulates Cortical Development
|
|---|---|
| Published in |
Journal of Neuroscience, February 2014
|
| DOI | 10.1523/jneurosci.2319-13.2014 |
| Pubmed ID | |
| Authors |
Michael Piper, Guy Barry, Tracey J. Harvey, Robert McLeay, Aaron G. Smith, Lachlan Harris, Sharon Mason, Brett W. Stringer, Bryan W. Day, Naomi R. Wray, Richard M. Gronostajski, Timothy L. Bailey, Andrew W. Boyd, Linda J. Richards |
| Abstract |
Epigenetic mechanisms are essential in regulating neural progenitor cell self-renewal, with the chromatin-modifying protein Enhancer of zeste homolog 2 (EZH2) emerging as a central player in promoting progenitor cell self-renewal during cortical development. Despite this, how Ezh2 is itself regulated remains unclear. Here, we demonstrate that the transcription factor nuclear factor IB (NFIB) plays a key role in this process. Nfib(-/-) mice exhibit an increased number of proliferative ventricular zone cells that express progenitor cell markers and upregulation of EZH2 expression within the neocortex and hippocampus. NFIB binds to the Ezh2 promoter and overexpression of NFIB represses Ezh2 transcription. Finally, key downstream targets of EZH2-mediated epigenetic repression are misregulated in Nfib(-/-) mice. Collectively, these results suggest that the downregulation of Ezh2 transcription by NFIB is an important component of the process of neural progenitor cell differentiation during cortical development. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Unknown | 63 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 33% |
| Researcher | 10 | 16% |
| Student > Bachelor | 6 | 9% |
| Student > Master | 5 | 8% |
| Student > Postgraduate | 4 | 6% |
| Other | 7 | 11% |
| Unknown | 11 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 30% |
| Biochemistry, Genetics and Molecular Biology | 13 | 20% |
| Neuroscience | 11 | 17% |
| Medicine and Dentistry | 8 | 13% |
| Psychology | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 11 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2014.
All research outputs
#14,647,929
of 22,745,803 outputs
Outputs from Journal of Neuroscience
#18,064
of 23,155 outputs
Outputs of similar age
#126,686
of 224,136 outputs
Outputs of similar age from Journal of Neuroscience
#210
of 316 outputs
Altmetric has tracked 22,745,803 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 23,155 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.3. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,136 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 316 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.