| Title |
The life of [PSI]
|
|---|---|
| Published in |
Current Genetics, June 2017
|
| DOI | 10.1007/s00294-017-0714-7 |
| Pubmed ID | |
| Authors |
Brian Cox, Mick Tuite |
| Abstract |
The AAA+ disaggregase Hsp104 is essential for the maintenance and inheritance of nearly all known prions of the yeast Saccharomyces cerevisiae. Uniquely for [PSI (+)], the prion form of the Sup35 protein, there seem to be two activities, involving differing co-chaperones, by which Hsp104 affects the inheritance of [PSI (+)], the prion form of the Sup35 protein. Each pathway is also involved in protection against ageing, one through disaggregation of damaged proteins and the other through their retention in the mother cell during budding. Mutations in both Hsp104 and Sup35 affect prion inheritance by one or other of these pathways, as does manipulation of either Hsp104 enzyme activity or expression, in both vegetative (budding) divisions and in sporulation. Based on our recent finding (Ness et al. in Molec Microbiol 104:125-143, 2017) we suggest that the management of the heritable prion forms of Sup35 in [PSI (+)] cells in sporulation may be a marker for a role for Hsp104 in rejuvenation during sporulation. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| France | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 50 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 27% |
| Researcher | 8 | 15% |
| Student > Ph. D. Student | 8 | 15% |
| Student > Master | 5 | 10% |
| Professor | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 11 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 29% |
| Agricultural and Biological Sciences | 9 | 17% |
| Physics and Astronomy | 6 | 12% |
| Philosophy | 3 | 6% |
| Chemistry | 2 | 4% |
| Other | 6 | 12% |
| Unknown | 11 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2023.
All research outputs
#15,631,278
of 23,857,313 outputs
Outputs from Current Genetics
#837
of 1,214 outputs
Outputs of similar age
#191,465
of 318,177 outputs
Outputs of similar age from Current Genetics
#7
of 27 outputs
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So far Altmetric has tracked 1,214 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
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