| Title |
The stem cell factor (SCF)/c‐KIT signalling in testis and prostate cancer
|
|---|---|
| Published in |
Journal of Cell Communication and Signaling, June 2017
|
| DOI | 10.1007/s12079-017-0399-1 |
| Pubmed ID | |
| Authors |
Henrique J. Cardoso, Marília I. Figueira, Sílvia Socorro |
| Abstract |
The stem cell factor (SCF) is a cytokine that specifically binds the tyrosine kinase receptor c-KIT. The SCF/c-KIT interaction leads to receptor dimerization, activation of kinase activity and initiation of several signal transduction pathways that control cell proliferation, apoptosis, differentiation and migration in several tissues. The activity of SCF/c-KIT system is linked with the phosphatidylinositol 3-kinase (PI3-K), the Src, the Janus kinase/signal transducers and activators of transcription (JAK/STAT), the phospholipase-C (PLC-γ) and the mitogen-activated protein kinase (MAPK) pathways. Moreover, it has been reported that cancer cases display an overactivation of c-KIT due to the presence of gain-of-function mutations or receptor overexpression, which renders c-KIT a tempting target for cancer treatment. In the case of male cancers the most documented activated pathways are the PI3-K and Src, both enhancing abnormal cell proliferation. It is also known that the Src activity in prostate cancer cases depends on the presence of tr-KIT, the cytoplasmic truncated variant of c-KIT that is specifically expressed in tumour tissues and, thus, a very interesting target for drug development. The present review provides an overview of the signalling pathways activated by SCF/c-KIT and discusses the potential application of c-KIT inhibitors for treatment of testicular and prostatic cancers. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 60 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 12 | 20% |
| Student > Ph. D. Student | 8 | 13% |
| Student > Master | 6 | 10% |
| Student > Doctoral Student | 5 | 8% |
| Other | 4 | 7% |
| Other | 10 | 17% |
| Unknown | 15 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 25% |
| Medicine and Dentistry | 10 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
| Agricultural and Biological Sciences | 4 | 7% |
| Nursing and Health Professions | 2 | 3% |
| Other | 7 | 12% |
| Unknown | 17 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2017.
All research outputs
#17,900,930
of 22,982,639 outputs
Outputs from Journal of Cell Communication and Signaling
#159
of 268 outputs
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#226,551
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Outputs of similar age from Journal of Cell Communication and Signaling
#6
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