Title |
Perspectives in Drug Development and Clinical Pharmacology: The Discovery of Histamine H1 and H2 Antagonists
|
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Published in |
Clinical Pharmacology in Drug Development, January 2016
|
DOI | 10.1002/cpdd.236 |
Pubmed ID | |
Authors |
Alan Wayne Jones |
Abstract |
Knowledge about the history and development of therapeutic agents holds a central position in the education and training of pharmacists and pharmacologists. Students enjoy learning about the discovery of drugs, including details about the pioneer workers involved (apothecaries, organic chemists, pharmacologists, and physiologists) and the role played by serendipity. The treatment of people suffering from allergies and the development of drugs that block the actions of histamine at H1 and H2 receptors are the subject of this review. Pharmaceutical products that block H1 receptors are widely used as prophylactic treatment for seasonal allergies that plague millions of people worldwide. The development of H2 receptor antagonists revolutionized treatment of gastric hyperacidity, the principal cause of peptic ulcers. Antihistamine research has changed focus toward the development of drugs that block the action of histamine at H3 and H4 receptors and the therapeutic potential is gradually being appreciated. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 12 | 32% |
Researcher | 5 | 14% |
Student > Ph. D. Student | 4 | 11% |
Student > Master | 3 | 8% |
Student > Doctoral Student | 2 | 5% |
Other | 2 | 5% |
Unknown | 9 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 16% |
Medicine and Dentistry | 6 | 16% |
Chemistry | 4 | 11% |
Agricultural and Biological Sciences | 3 | 8% |
Neuroscience | 3 | 8% |
Other | 6 | 16% |
Unknown | 9 | 24% |