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Appendectomy and the Risk of Colectomy in Ulcerative Colitis: A National Cohort Study

Overview of attention for article published in American Journal of Gastroenterology, June 2017
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Title
Appendectomy and the Risk of Colectomy in Ulcerative Colitis: A National Cohort Study
Published in
American Journal of Gastroenterology, June 2017
DOI 10.1038/ajg.2017.183
Pubmed ID
Authors

Pär Myrelid, Kalle Landerholm, Caroline Nordenvall, Thomas D Pinkney, Roland E Andersson

Abstract

Ulcerative colitis (UC) is a chronic inflammatory disease usually responding well to anti-inflammatory drugs but many patients will still need colectomy. Appendectomy is associated with a lower risk of later developing UC. We aimed to assess the longitudinal relationship between appendectomy, appendicitis, and disease course in UC patients. A national cohort of UC patients with a diagnosis in 1964-2010 was identified from the Swedish National Patient Register that also provided information regarding appendicitis and/or appendectomy before or after the UC diagnosis. The risk for colectomy and UC-related hospital admissions was evaluated. Among 63,711 UC patients, 2,143 had appendectomy and 7,690 underwent colectomy. Appendectomy for appendicitis before 20 years of age and for non-appendicitis at all ages before UC diagnosis was associated with a lower risk of colectomy (hazard ratio (HR) 0.44, 0.27-0.72 and HR 0.62, 0.43-0.90, respectively), and fewer hospital admissions (incidence rate ratio (IRR) 0.68, 95% confidence interval (CI) 0.64-0.73 and IRR 0.54, 0.47-0.63, respectively). Appendectomy for appendicitis after the UC diagnosis was associated with a higher risk of colectomy (HR 1.56, 1.20-2.03), whereas no such association was found for other pathology (HR 1.40, 0.79-2.47). Appendectomy early in life and before developing UC is associated with a lower risk of colectomy as well as UC-related hospital admissions. Appendectomy for appendicitis after established UC appears associated with a worse disease course, with an increased rate of subsequent colectomy.Am J Gastroenterol advance online publication, 27 June 2017; doi:10.1038/ajg.2017.183.

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The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 17%
Student > Master 9 12%
Researcher 8 11%
Student > Bachelor 6 8%
Other 5 7%
Other 11 14%
Unknown 24 32%
Readers by discipline Count As %
Medicine and Dentistry 30 39%
Immunology and Microbiology 5 7%
Biochemistry, Genetics and Molecular Biology 3 4%
Nursing and Health Professions 2 3%
Agricultural and Biological Sciences 2 3%
Other 9 12%
Unknown 25 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2019.
All research outputs
#7,915,082
of 25,728,855 outputs
Outputs from American Journal of Gastroenterology
#2,762
of 5,819 outputs
Outputs of similar age
#114,997
of 329,269 outputs
Outputs of similar age from American Journal of Gastroenterology
#27
of 43 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 5,819 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.8. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,269 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.