| Title |
Effect of transmission intensity on hotspots and micro-epidemiology of malaria in sub-Saharan Africa
|
|---|---|
| Published in |
BMC Medicine, June 2017
|
| DOI | 10.1186/s12916-017-0887-4 |
| Pubmed ID | |
| Authors |
Polycarp Mogeni, Irene Omedo, Christopher Nyundo, Alice Kamau, Abdisalan Noor, Philip Bejon, on behalf of The Hotspot Group Authors |
| Abstract |
Malaria transmission intensity is heterogeneous, complicating the implementation of malaria control interventions. We provide a description of the spatial micro-epidemiology of symptomatic malaria and asymptomatic parasitaemia in multiple sites. We assembled data from 19 studies conducted between 1996 and 2015 in seven countries of sub-Saharan Africa with homestead-level geospatial data. Data from each site were used to quantify spatial autocorrelation and examine the temporal stability of hotspots. Parameters from these analyses were examined to identify trends over varying transmission intensity. Significant hotspots of malaria transmission were observed in most years and sites. The risk ratios of malaria within hotspots were highest at low malaria positive fractions (MPFs) and decreased with increasing MPF (p < 0.001). However, statistical significance of hotspots was lowest at extremely low and extremely high MPFs, with a peak in statistical significance at an MPF of ~0.3. In four sites with longitudinal data we noted temporal instability and variable negative correlations between MPF and average age of symptomatic malaria across all sites, suggesting varying degrees of temporal stability. We observed geographical micro-variation in malaria transmission at sites with a variety of transmission intensities across sub-Saharan Africa. Hotspots are marked at lower transmission intensity, but it becomes difficult to show statistical significance when cases are sparse at very low transmission intensity. Given the predictability with which hotspots occur as transmission intensity falls, malaria control programmes should have a low threshold for responding to apparent clustering of cases. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 11% |
| United States | 1 | 11% |
| Germany | 1 | 11% |
| United Kingdom | 1 | 11% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 33% |
| Members of the public | 3 | 33% |
| Practitioners (doctors, other healthcare professionals) | 3 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 80 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 18% |
| Student > Master | 10 | 13% |
| Student > Ph. D. Student | 4 | 5% |
| Student > Postgraduate | 4 | 5% |
| Student > Doctoral Student | 4 | 5% |
| Other | 16 | 20% |
| Unknown | 28 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 24% |
| Agricultural and Biological Sciences | 9 | 11% |
| Immunology and Microbiology | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Nursing and Health Professions | 2 | 3% |
| Other | 9 | 11% |
| Unknown | 30 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2021.
All research outputs
#7,610,967
of 24,468,058 outputs
Outputs from BMC Medicine
#2,755
of 3,775 outputs
Outputs of similar age
#113,462
of 318,797 outputs
Outputs of similar age from BMC Medicine
#39
of 51 outputs
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