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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cell adhesion molecules and their relation to (cancer) cell stemness
|
|---|---|
| Published in |
Carcinogenesis, February 2014
|
| DOI | 10.1093/carcin/bgu045 |
| Pubmed ID | |
| Authors |
Ensieh Farahani, Hirak K. Patra, Jaganmohan R. Jangamreddy, Iran Rashedi, Marta Kawalec, Rama K. Rao Pariti, Petros Batakis, Emilia Wiechec |
| Abstract |
Despite decades of search for anticancer drugs targeting solid tumors, this group of diseases remains largely incurable, especially if in advanced, metastatic stage. In this review, we draw comparison between reprogramming and carcinogenesis, as well as between stem cells (SCs) and cancer stem cells (CSCs), focusing on changing garniture of adhesion molecules. Furthermore, we elaborate on the role of adhesion molecules in the regulation of (cancer) SCs division (symmetric or asymmetric), and in evolving interactions between CSCs and extracellular matrix. Among other aspects, we analyze the role and changes of expression of key adhesion molecules as cancer progresses and metastases develop. Here, the role of cadherins, integrins, as well as selected transcription factors like Twist and Snail is highlighted, not only in the regulation of epithelial-to-mesenchymal transition but also in the avoidance of anoikis. Finally, we briefly discuss recent developments and new strategies targeting CSCs, which focus on adhesion molecules or targeting tumor vasculature. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 226 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | <1% |
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 221 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 58 | 26% |
| Researcher | 40 | 18% |
| Student > Master | 34 | 15% |
| Student > Bachelor | 23 | 10% |
| Student > Doctoral Student | 17 | 8% |
| Other | 26 | 12% |
| Unknown | 28 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 61 | 27% |
| Agricultural and Biological Sciences | 53 | 23% |
| Medicine and Dentistry | 30 | 13% |
| Engineering | 13 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 4% |
| Other | 19 | 8% |
| Unknown | 41 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2014.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from Carcinogenesis
#4,056
of 4,884 outputs
Outputs of similar age
#216,681
of 345,135 outputs
Outputs of similar age from Carcinogenesis
#21
of 36 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,884 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,135 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.