| Title |
18F-Florbetaben PET beta-amyloid binding expressed in Centiloids
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, June 2017
|
| DOI | 10.1007/s00259-017-3749-6 |
| Pubmed ID | |
| Authors |
Christopher C. Rowe, Vincent Doré, Gareth Jones, David Baxendale, Rachel S. Mulligan, Santiago Bullich, Andrew W. Stephens, Susan De Santi, Colin L. Masters, Ludger Dinkelborg, Victor L. Villemagne |
| Abstract |
The Centiloid (CL) method enables quantitative values from Aβ-amyloid (Aβ) imaging to be expressed in a universal unit providing pathological, diagnostic and prognostic thresholds in clinical practice and research and allowing integration of multiple tracers and methods. The method was developed for (11)C-PiB scans with zero CL set as the average in young normal subjects and 100 CL the average in subjects with mild Alzheimer's disease (AD). The method allows derivation of equations to convert the uptake value of any tracer into the same standard CL units but first requires head-to-head comparison with (11)C-PiB results. We derived the equation to express (18)F-florbetaben (FBB) binding in CL units. Paired PiB and FBB PET scans were obtained in 35 subjects. including ten young normal subjects aged under 45 years (33 ± 8 years). FBB images were acquired from 90 to 110 min after injection. Spatially normalized images were analysed using the standard CL method (SPM8 coregistration of PET data to MRI data and the MNI-152 atlas) and standard CL regions (cortex and whole cerebellum downloaded from http://www.gaain.org ). FBB binding was strongly correlated with PiB binding (R (2) = 0.96, SUVRFBB = 0.61 × SUVRPiB + 0.39). The equation to derive CL values from FBB SUVR was CL units = 153.4 × SUVRFBB - 154.9. The CL value in the young normal subjects was -1.08 ± 6.81 for FBB scans compared to -0.32 ± 3.48 for PiB scans, giving a variance ratio of 1.96 (SDFBB CL/SDPiB CL). (18)F-FBB binding is strongly correlated with PiB binding and FBB results can now be expressed in CL units. |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 92 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 27% |
| Student > Ph. D. Student | 17 | 18% |
| Student > Master | 9 | 10% |
| Other | 6 | 7% |
| Student > Doctoral Student | 4 | 4% |
| Other | 8 | 9% |
| Unknown | 23 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 22 | 24% |
| Medicine and Dentistry | 16 | 17% |
| Engineering | 5 | 5% |
| Computer Science | 4 | 4% |
| Psychology | 4 | 4% |
| Other | 12 | 13% |
| Unknown | 29 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2023.
All research outputs
#3,165,157
of 24,387,992 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#293
of 3,394 outputs
Outputs of similar age
#57,036
of 320,707 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#4
of 42 outputs
Altmetric has tracked 24,387,992 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,394 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,707 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.