| Title |
Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells
|
|---|---|
| Published in |
Molecular Biology Reports, March 2007
|
| DOI | 10.1007/s11033-007-9059-5 |
| Pubmed ID | |
| Authors |
Ben-Zion Zaidman, Solomon P. Wasser, Eviatar Nevo, Jamal Mahajna |
| Abstract |
In this study, we screened a total of 201 diethyl ether, ethanol, and ethyl acetate fungal Basidiomycetes extracts for anti-androgenic activity. Based on our screened results in combination with the selective inhibition of prostate cancer LNCaP cells, we selected Coprinus comatus and Ganoderma lucidum for further evaluation. We demonstrated that ethanol and ethyl acetate extracts from C. comatus and G. lucidum, respectively, selectively inhibit dihydrotestosterone-induced LNCaP cell viability, suppress levels of secreted prostate-specific antigen in a dose-dependent manner, and cause a G1 phase arrest in LNCaP, but not in DU 145 and PC-3 cells. For the first time, to the best of our knowledge, we demonstrated that C. comatus and G. lucidum decreased androgen and glucocorticoide receptors transcriptional activity in breast cancer MDA-kb2 cells in a dose-dependent manner, and suppressed androgen receptor (AR) protein level in LNCaP and MDA-kb2 cells. Our findings suggest that AR and non-AR mediated mechanisms underlie the effects of C. comatus and G. lucidum. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 2 | 4% |
| Israel | 1 | 2% |
| Unknown | 54 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 32% |
| Researcher | 7 | 12% |
| Student > Bachelor | 5 | 9% |
| Student > Postgraduate | 5 | 9% |
| Professor > Associate Professor | 5 | 9% |
| Other | 8 | 14% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 32% |
| Medicine and Dentistry | 10 | 18% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Nursing and Health Professions | 2 | 4% |
| Other | 6 | 11% |
| Unknown | 10 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2019.
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#18,365,132
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Outputs from Molecular Biology Reports
#1,593
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Outputs of similar age
#70,913
of 75,822 outputs
Outputs of similar age from Molecular Biology Reports
#3
of 3 outputs
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