| Title |
The Toxoplasma gondii inhibitor-2 regulates protein phosphatase 1 activity through multiple motifs
|
|---|---|
| Published in |
Parasitology Research, June 2017
|
| DOI | 10.1007/s00436-017-5543-6 |
| Pubmed ID | |
| Authors |
Quentin Deveuve, Kevin Lesage, Thomas Mouveaux, Mathieu Gissot |
| Abstract |
Toxoplasma gondii has a complex life cycle characterized by multiple differentiation steps that are essential for its survival in both human and definitive feline host. Several studies have demonstrated the importance of phosphorylations by protein kinases during the life cycle of T. gondii. However, very little is known about protein phosphatases and their regulators in the parasite. We report the molecular and functional characterization of the T. gondii ortholog of the inhibitor-2 protein, designated TgI2. We show that TgI2 encompasses conserved motifs involved in the interaction and modulation of the phosphatase activity of T. gondii protein phosphatase 1, named TgPP1. We show that a specific combination of motifs is involved in binding and/or inhibition of the TgPP1 activity. We show here that the TgI2 protein is a potent inhibitor of TgPP1 phosphatase activity. TgI2 SILK and RVxF motifs are critical for regulating the activity of TgPP1, a feature that is common with the higher eukaryotes inhibitor-2 protein. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 25% |
| France | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 45% |
| Professor | 3 | 27% |
| Professor > Associate Professor | 1 | 9% |
| Researcher | 1 | 9% |
| Unknown | 1 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 45% |
| Agricultural and Biological Sciences | 2 | 18% |
| Computer Science | 1 | 9% |
| Unknown | 3 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2023.
All research outputs
#1,938,858
of 23,477,147 outputs
Outputs from Parasitology Research
#60
of 3,836 outputs
Outputs of similar age
#39,228
of 315,635 outputs
Outputs of similar age from Parasitology Research
#2
of 74 outputs
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So far Altmetric has tracked 3,836 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.