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A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats

Overview of attention for article published in FASEB Journal, February 2014
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Title
A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats
Published in
FASEB Journal, February 2014
DOI 10.1096/fj.14-249458
Pubmed ID
Authors

Sujoy Ghosh, Desiree Wanders, Kirsten P. Stone, Nancy T. Van, Cory C. Cortez, Thomas W. Gettys

Abstract

Dietary methionine restriction (MR) and calorie restriction (CR) each improve metabolic health and extend life span. We used comprehensive transcriptome profiling and systems biology analysis to interrogate the unique and overlapping molecular responses in rats provided these dietary regimens for 20 mo after weaning. Microarray analysis was conducted on inguinal white adipose (IWAT), brown adipose tissue (BAT), liver, and skeletal muscle. Compared to controls, CR-induced transcriptomic responses (absolute fold change ≥1.5 and P≤0.05) were comparable in IWAT, BAT, and liver (∼800 genes). MR-induced effects were largely restricted to IWAT and liver (∼2400 genes). Pathway enrichment and gene-coexpression analyses showed that induction of fatty acid synthesis in IWAT was common to CR and MR, whereas immunity and proinflammatory signaling pathways were specifically down-regulated in MR-treated IWAT and liver (FDR≤0.07-0.3). BAT demonstrated consistent down-regulation of PPAR-signaling under CR and MR, whereas muscle was largely unaffected. Interactome analysis identified CR-specific down-regulation of cytoskeletal matrix components in IWAT and MR-specific up-regulation of ribosomal genes in liver (FDR≤0.001). Transcriptomic down-regulation of inflammation genes by MR in IWAT was consistent with upstream inhibition of STAT3. Together, these results provide an integrated picture of the breadth of transcriptional responses to MR and CR among key metabolic tissues.-Ghosh, S., Wanders, D., Stone, K. P., Van, N. T., Cortez, C. C., Gettys, T. W. A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
France 1 2%
Korea, Republic of 1 2%
Brazil 1 2%
Unknown 42 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 20%
Researcher 6 13%
Professor > Associate Professor 5 11%
Student > Master 5 11%
Student > Doctoral Student 4 9%
Other 9 20%
Unknown 8 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 30%
Biochemistry, Genetics and Molecular Biology 12 26%
Medicine and Dentistry 4 9%
Sports and Recreations 2 4%
Economics, Econometrics and Finance 1 2%
Other 2 4%
Unknown 11 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2014.
All research outputs
#17,351,840
of 25,461,852 outputs
Outputs from FASEB Journal
#7,599
of 11,468 outputs
Outputs of similar age
#142,484
of 235,248 outputs
Outputs of similar age from FASEB Journal
#74
of 110 outputs
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So far Altmetric has tracked 11,468 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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