| Title |
Cortical thickness abnormalities in trichotillomania: international multi-site analysis
|
|---|---|
| Published in |
Brain Imaging and Behavior, June 2017
|
| DOI | 10.1007/s11682-017-9746-3 |
| Pubmed ID | |
| Authors |
Samuel R. Chamberlain, Michael Harries, Sarah A. Redden, Nancy J. Keuthen, Dan J. Stein, Christine Lochner, Jon E. Grant |
| Abstract |
Trichotillomania is a prevalent but often hidden psychiatric condition, characterized by repetitive hair pulling. The aim of this study was to confirm or refute structural brain abnormalities in trichotillomania by pooling all available global data. De-identified MRI scans were pooled by contacting authors of previous studies. Cortical thickness and sub-cortical volumes were compared between patients and controls. Patients (n = 76) and controls (n = 41) were well-matched in terms of demographic characteristics. Trichotillomania patients showed excess cortical thickness in a cluster maximal at right inferior frontal gyrus, unrelated to symptom severity. No significant sub-cortical volume differences were detected in the regions of interest. Morphometric changes in the right inferior frontal gyrus appear to play a central role in the pathophysiology of trichotillomania, and to be trait in nature. The findings are distinct from other impulsive-compulsive disorders (OCD, ADHD, gambling disorder), which have typically been associated with reduced, rather than increased, cortical thickness. Future work should examine sub-cortical and cerebellar morphology using analytic approaches designed for this purpose, and should also characterize grey matter densities/volumes. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 22% |
| South Africa | 1 | 11% |
| Unknown | 6 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 33% |
| Science communicators (journalists, bloggers, editors) | 2 | 22% |
| Practitioners (doctors, other healthcare professionals) | 2 | 22% |
| Members of the public | 2 | 22% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 16% |
| Student > Ph. D. Student | 9 | 12% |
| Student > Bachelor | 7 | 9% |
| Other | 7 | 9% |
| Student > Postgraduate | 5 | 7% |
| Other | 13 | 17% |
| Unknown | 22 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 14 | 19% |
| Medicine and Dentistry | 12 | 16% |
| Neuroscience | 9 | 12% |
| Nursing and Health Professions | 2 | 3% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 8 | 11% |
| Unknown | 28 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2021.
All research outputs
#4,905,574
of 23,577,654 outputs
Outputs from Brain Imaging and Behavior
#303
of 1,165 outputs
Outputs of similar age
#84,009
of 316,452 outputs
Outputs of similar age from Brain Imaging and Behavior
#8
of 23 outputs
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So far Altmetric has tracked 1,165 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 73% of its peers.
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.