| Title |
Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding
|
|---|---|
| Published in |
Diabetologia, February 2014
|
| DOI | 10.1007/s00125-014-3198-8 |
| Pubmed ID | |
| Authors |
Stine C. Jacobsen, Linn Gillberg, Jette Bork-Jensen, Rasmus Ribel-Madsen, Ester Lara, Vincenzo Calvanese, Charlotte Ling, Agustin F. Fernandez, Mario F. Fraga, Pernille Poulsen, Charlotte Brøns, Allan Vaag |
| Abstract |
The association between low birthweight (LBW) and risk of developing type 2 diabetes may involve epigenetic mechanisms, with skeletal muscle being a prime target tissue. Differential DNA methylation patterns have been observed in single genes in muscle tissue from type 2 diabetic and LBW individuals, and we recently showed multiple DNA methylation changes during short-term high-fat overfeeding in muscle of healthy people. In a randomised crossover study, we analysed genome-wide DNA promoter methylation in skeletal muscle of 17 young LBW men and 23 matched normal birthweight (NBW) men after a control and a 5 day high-fat overfeeding diet. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Norway | 1 | 33% |
| United Kingdom | 1 | 33% |
| Spain | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 98 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 15% |
| Researcher | 14 | 14% |
| Student > Master | 14 | 14% |
| Student > Bachelor | 7 | 7% |
| Student > Doctoral Student | 5 | 5% |
| Other | 17 | 17% |
| Unknown | 28 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 25% |
| Biochemistry, Genetics and Molecular Biology | 17 | 17% |
| Agricultural and Biological Sciences | 7 | 7% |
| Nursing and Health Professions | 5 | 5% |
| Neuroscience | 3 | 3% |
| Other | 14 | 14% |
| Unknown | 29 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2014.
All research outputs
#14,190,698
of 22,745,803 outputs
Outputs from Diabetologia
#4,312
of 5,032 outputs
Outputs of similar age
#118,084
of 221,189 outputs
Outputs of similar age from Diabetologia
#35
of 55 outputs
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