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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hypoxia Enhances the Radioresistance of Mouse Mesenchymal Stromal Cells
|
|---|---|
| Published in |
Stem Cells, July 2014
|
| DOI | 10.1002/stem.1683 |
| Pubmed ID | |
| Authors |
Tara Sugrue, Noel F. Lowndes, Rhodri Ceredig |
| Abstract |
Mesenchymal stromal cells (MSCs) are radio-resistant bone marrow progenitors that support hematopoiesis and its re-constitution following total body irradiation. MSCs reside in hypoxic niches within the bone marrow and tumor microenvironments. The DNA Damage Response (DDR) represents a network of signaling pathways that enable cells to activate biological responses to DNA damaging agents. Hypoxia-mediated alterations in the DDR contribute to the increased radio-resistance of hypoxic cancer cells, limiting therapeutic efficacy. The DDR is important in mediating mouse MSC radio-resistance. However, the effects of hypoxia on MSC radio-resistance are currently unknown. In this report, hypoxia was found to (i) increase MSC proliferation rate and colony size; (ii) increase long-term survival post irradiation and (iii) improve MSC recovery from IR-induced cell cycle arrest. DNA DSB repair in MSCs was up-regulated in hypoxia, accelerating the resolution of highly genotoxic IR-induced DNA double-strand breaks (DSBs). In addition, HIF-1α was found to contribute to this enhanced DSB repair by regulating (i) the expression of DNA ligase IV and DNA-PKcs and (ii) Rad51 foci formation in response to DNA DSBs in hypoxic MSCs. We have demonstrated, for the first time, that hypoxia enhances mouse MSC radio-resistance in vitro. These findings have important implications for our understanding of MSC functions in supporting allogeneic bone marrow transplantation and in tumorigenesis. Stem Cells 2014. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Unknown | 26 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 19% |
| Researcher | 5 | 19% |
| Student > Ph. D. Student | 5 | 19% |
| Student > Doctoral Student | 3 | 11% |
| Student > Master | 3 | 11% |
| Other | 3 | 11% |
| Unknown | 3 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 33% |
| Biochemistry, Genetics and Molecular Biology | 5 | 19% |
| Medicine and Dentistry | 5 | 19% |
| Immunology and Microbiology | 2 | 7% |
| Physics and Astronomy | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 4 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2014.
All research outputs
#13,072,573
of 23,577,654 outputs
Outputs from Stem Cells
#2,886
of 3,942 outputs
Outputs of similar age
#102,835
of 228,603 outputs
Outputs of similar age from Stem Cells
#34
of 67 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,942 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,603 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.