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GWAS follow-up study of esophageal squamous cell carcinoma identifies potential genetic loci associated with family history of upper gastrointestinal cancer

Overview of attention for article published in Scientific Reports, July 2017
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Title
GWAS follow-up study of esophageal squamous cell carcinoma identifies potential genetic loci associated with family history of upper gastrointestinal cancer
Published in
Scientific Reports, July 2017
DOI 10.1038/s41598-017-04822-2
Pubmed ID
Authors

Xin Song, Wen-Qing Li, Nan Hu, Xue Ke Zhao, Zhaoming Wang, Paula L. Hyland, Tao Jiang, Guo Qiang Kong, Hua Su, Chaoyu Wang, Lemin Wang, Li Sun, Zong Min Fan, Hui Meng, Tang Juan Zhang, Ling Fen Ji, Shou Jia Hu, Wei Li Han, Min Jie Wu, Peng Yuan Zheng, Shuang Lv, Xue Min Li, Fu You Zhou, Laurie Burdett, Ti Ding, You-Lin Qiao, Jin-Hu Fan, Xiao-You Han, Carol Giffen, Margaret A. Tucker, Sanford M. Dawsey, Neal D. Freedman, Stephen J. Chanock, Christian C. Abnet, Philip R. Taylor, Li-Dong Wang, Alisa M. Goldstein

Abstract

Based on our initial genome-wide association study (GWAS) on esophageal squamous cell carcinoma (ESCC) in Han Chinese, we conducted a follow-up study to examine the single nucleotide polymorphisms (SNPs) associated with family history (FH) of upper gastrointestinal cancer (UGI) cancer in cases with ESCC. We evaluated the association between SNPs and FH of UGI cancer among ESCC cases in a stage-1 case-only analysis of the National Cancer Institute (NCI, 541 cases with FH and 1399 without FH) and Henan GWAS (493 cases with FH and 869 without FH) data (discovery phase). The top SNPs (or their surrogates) from discovery were advanced to a stage-2 evaluation in additional Henan subjects (2801 cases with FH and 3136 without FH, replication phase). A total of 19 SNPs were associated with FH of UGI cancer in ESCC cases with P < 10(-5) in the stage-1 meta-analysis of NCI and Henan GWAS data. In stage-2, the association for rs79747906 (located at 18p11.31, P = 5.79 × 10(-6) in discovery) was replicated (P = 0.006), with a pooled-OR of 1.59 (95%CI: 1.11-2.28). We identified potential genetic variants associated with FH of UGI cancer. Our findings may provide important insights into new low-penetrance susceptibility regions involved in the susceptibility of families with multiple UGI cancer cases.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 14%
Student > Ph. D. Student 3 14%
Student > Bachelor 2 10%
Student > Postgraduate 2 10%
Student > Master 2 10%
Other 4 19%
Unknown 5 24%
Readers by discipline Count As %
Medicine and Dentistry 8 38%
Biochemistry, Genetics and Molecular Biology 3 14%
Agricultural and Biological Sciences 2 10%
Unspecified 1 5%
Environmental Science 1 5%
Other 1 5%
Unknown 5 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2017.
All research outputs
#18,558,284
of 22,985,065 outputs
Outputs from Scientific Reports
#93,935
of 124,097 outputs
Outputs of similar age
#239,787
of 313,319 outputs
Outputs of similar age from Scientific Reports
#3,551
of 5,029 outputs
Altmetric has tracked 22,985,065 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 124,097 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,319 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,029 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.