| Title |
RETRACTED ARTICLE: Canine transmissible venereal tumor and seminoma: a cytohistopathology and chemotherapy study of tumors in the growth phase and during regression after chemotherapy
|
|---|---|
| Published in |
Tumor Biology, February 2014
|
| DOI | 10.1007/s13277-014-1723-5 |
| Pubmed ID | |
| Authors |
J. Javanbakht, B. Pedram, M. R. Taheriyan, F. Khadivar, S. H. Hosseini, F. S. Abdi, E. Hosseini, M. Moloudizargari, S H. Aghajanshakeri, S. Javaherypour, R. Shafiee, R. Emrani Bidi |
| Abstract |
In this study, 12 dogs affected by canine transmissible venereal tumor (CTVT) and testicular seminoma tumor were studied retrospectively. The cytological sample was smeared onto a glass slide and either air-dried for May-Grünwald-stain, and masses were surgically removed. The tumors were grossly examined, and sections of 4-μm thick were obtained from each sample and stained with H&E. For chemotherapy, vincristine sulfate was administered weekly as an infusion over 3 min via the cephalic vein at a dose of 0.025 mg/kg after diluting with physiological saline to a total amount of 10 ml. If no remission was observed after 8 weeks, chemotherapy was continued with weekly doxorubicin infusion at a dose of 1 mg/kg. All the tumor samples were divided into four cytohistopathologic groups, namely: multilobular (six cases), papillary (two cases), pedunculated (two cases), and tubular (two cases of seminoma). The most frequently represented tumor type was multilobular (6/10, 60 %) followed by pedunculated (2/10, 20 %), papillary (2/10, 20 %), and tubular (two cases of seminoma, 100 %). Cytological smears from eight tumors in regression after chemotherapy were poorly cellular, and many cells were fragmented. In two progressive tumors, there was an average of 1,406 ± 972 CTVT 200 cells/μl or 96 · 71 % of total cells counted. Thus, tumor cells represented 96 · 71 % of total cells within the biopsy specimens and the leukocytes 4 · 29 % (leukocyte, tumor cell ratio = 0 · 062 ± 0 · 031). In eight regressive tumors, there was an average of 1,245 ± 1,032 CTVT 200 cells/μl or 97 · 31 % of total cells counted. Thus, tumor cells represented 97 · 31 % of total cells and leukocytes 2 · 69 % (leukocyte, tumor cell ratio = 0 · 071 ± 0 · 174). Our data suggested that combination treatment with vincristine and doxorubicin in the future could be an excellent therapeutic alternative for the treatment of TVT for probably reducing the resistance to vincristine, and also, treatment success could easily be followed by the cytological changes. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 29% |
| Student > Bachelor | 3 | 18% |
| Other | 2 | 12% |
| Student > Postgraduate | 2 | 12% |
| Student > Ph. D. Student | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 4 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 24% |
| Veterinary Science and Veterinary Medicine | 3 | 18% |
| Medicine and Dentistry | 3 | 18% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Unknown | 6 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2014.
All research outputs
#20,221,866
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Outputs from Tumor Biology
#1,834
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Outputs of similar age
#193,067
of 224,442 outputs
Outputs of similar age from Tumor Biology
#37
of 51 outputs
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