| Title |
Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis
|
|---|---|
| Published in |
Parasitology Research, January 2012
|
| DOI | 10.1007/s00436-012-2830-0 |
| Pubmed ID | |
| Authors |
Angelica Olivo-Diaz, Mirza Romero-Valdovinos, Areli Gudiño-Ramirez, Jesus Reyes-Gordillo, Diego Emiliano Jimenez-Gonzalez, Maria Elena Ramirez-Miranda, Williams Arony Martinez-Flores, Fernando Martinez-Hernandez, Ana Flisser, Pablo Maravilla |
| Abstract |
The intestinal protozoan parasite Blastocystis is one of the most common parasites worldwide in humans and, although its ability to cause human disease has been questioned, some reports have demonstrated that this microorganism is associated to the development of irritable bowel syndrome (IBS) and to a proinflammatory response, in which the expression of some cytokines is unregulated. Since inflammatory cytokine gene polymorphisms might have a role in the pathophysiology of IBS, we assessed the role of single nucleotide polymorphisms (SNPs) for interleukin (IL)-8 and IL-10, in previously collected DNA samples from IBS patients and controls, with or without Blastocystis infection. IL-8+396(G) and IL-10-1082 (A) alleles (p=0.0437 and p=0.0267, respectively), as well as their homozygous (p<0.0001 and p=0.0039, respectively) and IL-8+781(CT) (p=0.0248) genotypes were significantly overrepresented in patients with IBS in comparison with controls. IL-8+396(GG) genotype was relevant because it was associated to IBS (p<0.0001), to Blastocystis (p=0.0025), and to IBS–Blastocystis (p=0.0272). In the latter binomial association, this genotype presented a high contribution (etiological fraction =0.452) and a risk >fourfold to develop IBS. IL-8+781 (T) and IL-10-592 (C) alleles were also associated to Blastocystis and to IBS–Blastocystis, respectively (p=0.0448 and p=0.0166). Our results suggest that some IL-8 and IL-10 SNPs could change individual susceptibility increasing the relative risk in the development of IBS in Blastocystis carriers. |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 22% |
| Student > Ph. D. Student | 6 | 15% |
| Student > Bachelor | 6 | 15% |
| Professor > Associate Professor | 3 | 7% |
| Student > Master | 3 | 7% |
| Other | 9 | 22% |
| Unknown | 5 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 32% |
| Agricultural and Biological Sciences | 9 | 22% |
| Biochemistry, Genetics and Molecular Biology | 5 | 12% |
| Immunology and Microbiology | 2 | 5% |
| Veterinary Science and Veterinary Medicine | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 6 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2014.
All research outputs
#5,861,297
of 22,745,803 outputs
Outputs from Parasitology Research
#398
of 3,778 outputs
Outputs of similar age
#52,867
of 246,605 outputs
Outputs of similar age from Parasitology Research
#6
of 35 outputs
Altmetric has tracked 22,745,803 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 3,778 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.