| Title |
Degradation of human secretory immunoglobulin A by Blastocystis
|
|---|---|
| Published in |
Parasitology Research, September 2005
|
| DOI | 10.1007/s00436-005-1461-0 |
| Pubmed ID | |
| Authors |
Manoj K. Puthia, Aparna Vaithilingam, Jia Lu, Kevin S. W. Tan |
| Abstract |
Microbial immunoglobulin A (IgA) proteases cleave human secretory IgA, promoting the mucosal adhesion of pathogens. To investigate if the enteric protozoan Blastocystis degrades human secretory IgA, cell lysate and conditioned medium from two species were exposed to immunoglobulin A. Secretory IgA was cleaved by both cell lysate and conditioned medium with mainly cysteine proteinase activity in B. hominis B isolate and aspartic proteinase activity in B. ratii WR1 isolate. These findings suggest that Blastocystis proteases may play a role in parasite survival in vivo. |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 1% |
| South Africa | 1 | 1% |
| Unknown | 70 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 21% |
| Researcher | 11 | 15% |
| Student > Master | 6 | 8% |
| Student > Doctoral Student | 6 | 8% |
| Student > Ph. D. Student | 5 | 7% |
| Other | 14 | 19% |
| Unknown | 15 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 22% |
| Biochemistry, Genetics and Molecular Biology | 13 | 18% |
| Agricultural and Biological Sciences | 9 | 13% |
| Nursing and Health Professions | 6 | 8% |
| Immunology and Microbiology | 6 | 8% |
| Other | 5 | 7% |
| Unknown | 17 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2014.
All research outputs
#3,772,378
of 22,745,803 outputs
Outputs from Parasitology Research
#201
of 3,778 outputs
Outputs of similar age
#8,775
of 58,674 outputs
Outputs of similar age from Parasitology Research
#1
of 6 outputs
Altmetric has tracked 22,745,803 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,778 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 58,674 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them