| Title |
Synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids
|
|---|---|
| Published in |
Molecular Diversity, April 2017
|
| DOI | 10.1007/s11030-017-9737-8 |
| Pubmed ID | |
| Authors |
Andrii Lozynskyi, Viktoria Zasidko, Dmytro Atamanyuk, Danylo Kaminskyy, Halyna Derkach, Olexandr Karpenko, Volodymyr Ogurtsov, Roman Kutsyk, Roman Lesyk |
| Abstract |
Here it is described the synthesis, antioxidant and antimicrobial activity determination of novel rel-([Formula: see text])-6-benzoyl-7-phenyl-2-oxo-3,5,6,7-tetrahydro-2H-thiopyrano[2,3-d]thiazole-5-carboxylic acids. The target compounds were obtained in good yields from 5-arylidene-4-thioxo-2-thiazolidinones and [Formula: see text]-aroylacrylic acids via regio- and diastereoselective hetero-Diels-Alder reaction. The stereochemistry of the cycloaddition was confirmed by NMR spectra. The antioxidant and antimicrobial activity screening identified 7 compounds (3c, 3e, 3f, 3g, 3k, 3l, 3p) with a high level of free radical scavenging (43-77% DPPH assay), and compounds with significant influence on Staphylococcus aureus, Bacillus subtilis and Candida albicans (MIC 3.13-6.25 [Formula: see text]), but slight effect on Escherichia coli. |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 18 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 17% |
| Unspecified | 2 | 11% |
| Researcher | 2 | 11% |
| Professor > Associate Professor | 2 | 11% |
| Student > Bachelor | 1 | 6% |
| Other | 4 | 22% |
| Unknown | 4 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 5 | 28% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 17% |
| Unspecified | 2 | 11% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Immunology and Microbiology | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 5 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2019.
All research outputs
#5,799,012
of 22,985,065 outputs
Outputs from Molecular Diversity
#107
of 470 outputs
Outputs of similar age
#91,692
of 310,364 outputs
Outputs of similar age from Molecular Diversity
#1
of 4 outputs
Altmetric has tracked 22,985,065 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 470 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,364 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them