| Title |
Single-Nucleotide Polymorphisms in the KCNN3 Gene Associate With Preterm Birth
|
|---|---|
| Published in |
Reproductive Sciences, December 2011
|
| DOI | 10.1177/1933719110391277 |
| Pubmed ID | |
| Authors |
Lori J. Day, Kendra L. Schaa, Kelli K. Ryckman, Meg Cooper, John M. Dagle, Chin-To Fong, Hyagriv N. Simhan, David C. Merrill, Mary L. Marazita, Jeffrey C. Murray, Sarah K. England |
| Abstract |
The objectives were to determine whether single-nucleotide polymorphisms (SNPs) in KCNN3 (encodes the small conductance calcium-activated potassium channel subfamily N, member 3), associate with preterm birth (PTB). In all, 602 preterm families with at least 1 preterm (<37 weeks gestation) infant were studied: DNA from the infant and one or both parents were genotyped for 16 SNPs in KCNN3. A region of interest within KCNN3 was sequenced in 512 Caucasian non-Hispanic mothers (412 with preterm deliveries;100 who delivered at term). Family-based association testing was used for genotyping analysis; Fisher exact test was used for sequencing analysis. Six SNPs (rs1218585, rs4845396, rs12058931, rs1218568, rs6426985, and rs4845394) were associated with PTB (all Ps < .05). These variations were all located within the intronic region between exons 1 and 2. Maternal sequencing revealed an association of 3 SNPs with spontaneous PTB; rs1218585 (P = .007), rs1218584 (P = .05), and a novel SNP at chromosome1:153099353 (P = .02). Polymorphisms in KCNN3 are associated with PTB and investigation into the functional significance of these allelic changes is warranted. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 12 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 17% |
| Librarian | 1 | 8% |
| Other | 1 | 8% |
| Professor | 1 | 8% |
| Student > Master | 1 | 8% |
| Other | 2 | 17% |
| Unknown | 4 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 25% |
| Medicine and Dentistry | 2 | 17% |
| Sports and Recreations | 1 | 8% |
| Social Sciences | 1 | 8% |
| Neuroscience | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 4 | 33% |
Attention Score in Context
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#15,294,762
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Outputs from Reproductive Sciences
#501
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#163,140
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Outputs of similar age from Reproductive Sciences
#26
of 36 outputs
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