| Title |
Corin in Natriuretic Peptide Processing and Hypertension
|
|---|---|
| Published in |
Current Hypertension Reports, January 2014
|
| DOI | 10.1007/s11906-013-0415-7 |
| Pubmed ID | |
| Authors |
Yiqing Zhou, Qingyu Wu |
| Abstract |
Corin is a serine protease originally isolated from the heart. Functional studies show that corin is the long-sought enzyme responsible for activating cardiac natriuretic peptides. In mice, lack of corin prevents natriuretic peptide processing, causing salt-sensitive hypertension. In humans, corin variants and mutations that reduce corin activity have been identified in patients with hypertension and heart failure. Decreased plasma levels of corin antigen and activity have been reported in patients with heart failure and coronary artery disease. Low levels of urinary corin also have been found in patients with chronic kidney disease. Most recent studies show that corin also acts in the uterus to promote spiral artery remodeling and prevent pregnancy-induced hypertension. Here, we review the role of corin in natriuretic peptide processing and cardiovascular diseases such as hypertension, heart disease, pre-eclampsia, and chronic kidney disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 18% |
| Student > Ph. D. Student | 2 | 18% |
| Unspecified | 1 | 9% |
| Student > Bachelor | 1 | 9% |
| Student > Master | 1 | 9% |
| Other | 0 | 0% |
| Unknown | 4 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 36% |
| Agricultural and Biological Sciences | 1 | 9% |
| Unspecified | 1 | 9% |
| Immunology and Microbiology | 1 | 9% |
| Engineering | 1 | 9% |
| Other | 0 | 0% |
| Unknown | 3 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2014.
All research outputs
#18,366,246
of 22,747,498 outputs
Outputs from Current Hypertension Reports
#549
of 732 outputs
Outputs of similar age
#228,915
of 304,970 outputs
Outputs of similar age from Current Hypertension Reports
#7
of 14 outputs
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