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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
|
|---|---|
| Published in |
Nature Methods, March 2014
|
| DOI | 10.1038/nmeth.2857 |
| Pubmed ID | |
| Authors |
Bin Shen, Wensheng Zhang, Jun Zhang, Jiankui Zhou, Jianying Wang, Li Chen, Lu Wang, Alex Hodgkins, Vivek Iyer, Xingxu Huang, William C Skarnes |
| Abstract |
Bacterial RNA-directed Cas9 endonuclease is a versatile tool for site-specific genome modification in eukaryotes. Co-microinjection of mouse embryos with Cas9 mRNA and single guide RNAs induces on-target and off-target mutations that are transmissible to offspring. However, Cas9 nickase can be used to efficiently mutate genes without detectable damage at known off-target sites. This method is applicable for genome editing of any model organism and minimizes confounding problems of off-target mutations. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 20% |
| United States | 2 | 20% |
| Germany | 1 | 10% |
| Ireland | 1 | 10% |
| France | 1 | 10% |
| Antarctica | 1 | 10% |
| South Africa | 1 | 10% |
| Unknown | 1 | 10% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 50% |
| Members of the public | 5 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,405 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 1% |
| United Kingdom | 9 | <1% |
| Germany | 6 | <1% |
| Switzerland | 3 | <1% |
| Spain | 3 | <1% |
| Portugal | 2 | <1% |
| Denmark | 2 | <1% |
| Japan | 2 | <1% |
| Finland | 2 | <1% |
| Other | 10 | <1% |
| Unknown | 1350 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 341 | 24% |
| Researcher | 288 | 20% |
| Student > Master | 179 | 13% |
| Student > Bachelor | 154 | 11% |
| Student > Doctoral Student | 77 | 5% |
| Other | 193 | 14% |
| Unknown | 173 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 583 | 41% |
| Biochemistry, Genetics and Molecular Biology | 411 | 29% |
| Medicine and Dentistry | 75 | 5% |
| Immunology and Microbiology | 28 | 2% |
| Neuroscience | 22 | 2% |
| Other | 92 | 7% |
| Unknown | 194 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 62. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#702,724
of 26,017,215 outputs
Outputs from Nature Methods
#910
of 5,404 outputs
Outputs of similar age
#6,445
of 240,495 outputs
Outputs of similar age from Nature Methods
#16
of 88 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,404 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.8. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,495 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.