| Title |
Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood
|
|---|---|
| Published in |
Acta Neuropathologica, July 2017
|
| DOI | 10.1007/s00401-017-1747-1 |
| Pubmed ID | |
| Authors |
Nora Hagemeyer, Klara-Maria Hanft, Maria-Anna Akriditou, Nicole Unger, Eun S. Park, E. Richard Stanley, Ori Staszewski, Leda Dimou, Marco Prinz |
| Abstract |
Whereas microglia involvement in virtually all brain diseases is well accepted their role in the control of homeostasis in the central nervous system (CNS) is mainly thought to be the maintenance of neuronal function through the formation, refinement, and monitoring of synapses in both the developing and adult brain. Although the prenatal origin as well as the neuron-centered function of cortical microglia has recently been elucidated, much less is known about a distinct amoeboid microglia population formerly described as the "fountain of microglia" that appears only postnatally in myelinated regions such as corpus callosum and cerebellum. Using large-scale transcriptional profiling, fate mapping, and genetic targeting approaches, we identified a unique molecular signature of this microglia subset that arose from a CNS endogenous microglia pool independent from circulating myeloid cells. Microglia depletion experiments revealed an essential role of postnatal microglia for the proper development and homeostasis of oligodendrocytes and their progenitors. Our data provide new cellular and molecular insights into the myelin-supporting function of microglia in the normal CNS. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 20% |
| United States | 2 | 13% |
| France | 1 | 7% |
| Sweden | 1 | 7% |
| Unknown | 8 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 47% |
| Scientists | 6 | 40% |
| Science communicators (journalists, bloggers, editors) | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 419 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 419 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 92 | 22% |
| Researcher | 51 | 12% |
| Student > Bachelor | 47 | 11% |
| Student > Master | 42 | 10% |
| Student > Doctoral Student | 23 | 5% |
| Other | 40 | 10% |
| Unknown | 124 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 109 | 26% |
| Biochemistry, Genetics and Molecular Biology | 68 | 16% |
| Agricultural and Biological Sciences | 45 | 11% |
| Medicine and Dentistry | 21 | 5% |
| Immunology and Microbiology | 14 | 3% |
| Other | 33 | 8% |
| Unknown | 129 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2023.
All research outputs
#2,941,614
of 25,375,376 outputs
Outputs from Acta Neuropathologica
#715
of 2,544 outputs
Outputs of similar age
#50,989
of 319,720 outputs
Outputs of similar age from Acta Neuropathologica
#12
of 38 outputs
Altmetric has tracked 25,375,376 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,544 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,720 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.