| Title |
Intravenous paracetamol vs ibuprofen in renal colic: a randomised, double-blind, controlled clinical trial
|
|---|---|
| Published in |
Urolithiasis, July 2017
|
| DOI | 10.1007/s00240-017-0997-7 |
| Pubmed ID | |
| Authors |
E. Cenker, M. Serinken, E. Uyanık |
| Abstract |
Pain management is one of the essentials of emergency care. Renal colic secondary to urinary stone disease forms one of the most intense pain types. The present study aimed to compare the effect of intravenous ibuprofen to paracetamol in ceasing renal colic. This randomised double-blind study was composed of two intervention arms, intravenous paracetamol and intravenous ibuprofen. Study subjects were randomised to receive a single dose of either paracetamol, 1 g in 100 ml normal saline, or ibuprofen (800 mg in 100 ml normal saline) in a blinded fashion. Subjects reported pain intensity on a visual analogue scale with lines intersection multiples of ten just before the drug administration, 15 and 30 min after the study drug administration. Two hundred patients were randomised to either of two study arms: however, 97 patients in ibuprofen group and 99 patients in paracetamol groups were included into 30 minute analysis. Differences of pain improvements between two groups was 9.5 (5.4-13.7) at 15 min (p = 0.000) and 17.1 (11.9-22.5) at 30 min, those both favouring ibuprofen over paracetamol (p = 0.000). Although ten (10.1%) patients in paracetamol group needed rescue drug, there were only two (2%) patients in ibuprofen group (difference: 8%; 95% CI 0.7-16%, p = 0.02). Intravenous 800 mg ibuprofen is more effective than IV paracetamol in ceasing renal colic at 30 min. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 20% |
| Researcher | 4 | 10% |
| Student > Doctoral Student | 3 | 7% |
| Student > Ph. D. Student | 3 | 7% |
| Other | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 15 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 34% |
| Nursing and Health Professions | 4 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Unspecified | 2 | 5% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 15 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2018.
All research outputs
#18,558,284
of 22,985,065 outputs
Outputs from Urolithiasis
#261
of 330 outputs
Outputs of similar age
#239,787
of 313,319 outputs
Outputs of similar age from Urolithiasis
#7
of 8 outputs
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