| Title |
Lack of replication of genetic associations with human longevity
|
|---|---|
| Published in |
Biogerontology, November 2007
|
| DOI | 10.1007/s10522-007-9116-4 |
| Pubmed ID | |
| Authors |
Valeria Novelli, Chiara Viviani Anselmi, Roberta Roncarati, Guia Guffanti, Alberto Malovini, Giulio Piluso, Annibale Alessandro Puca |
| Abstract |
The exceptional longevity of centenarians is due in part to inherited genetic factors, as deduced from data that show that first degree relatives of centenarians live longer and have reduced overall mortality. In recent years, a number of groups have performed genetic association studies on long-living individuals (LLI) and young controls to identify alleles that are either positively or negatively selected in the centenarian population as consequence of a demographic pressure. Many of the reported studies have shown genetic loci associated with longevity. Of these, with the exception of APOE, none have been convincingly reproduced. We validated our populations by typing the APOE locus. In addition, we used 749 American Caucasian LLI, organized in two independent tiers and 355 American Caucasian controls in the attempt to replicate previously published findings. We tested Klotho (KL)-VS variant (rs952706), Cholesteryl Ester Transfer Protein (CETP) I405V (rs5882), Paraoxonase 1 (PON1) Q192R (rs662), Apolipoprotein C-III (APOC3) -641C/A (rs2542052), Microsomal Transfer Protein (MTP) -493G/T (rs2866164) and apolipoprotein E (APOE) epsilon2 and epsilon4 isoforms, (rs7412 and rs429358) haplotypes respectively. Our results show that, at present, except for APOE, none of the selected genes show association with longevity if carefully tested in a large cohort of LLI and their controls, pointing to the need of larger populations for case-control studies in extreme longevity. |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 2% |
| Costa Rica | 1 | 2% |
| Unknown | 45 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 21% |
| Student > Ph. D. Student | 7 | 15% |
| Professor | 6 | 13% |
| Student > Bachelor | 5 | 11% |
| Student > Doctoral Student | 4 | 9% |
| Other | 13 | 28% |
| Unknown | 2 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 30% |
| Medicine and Dentistry | 11 | 23% |
| Biochemistry, Genetics and Molecular Biology | 5 | 11% |
| Psychology | 4 | 9% |
| Neuroscience | 3 | 6% |
| Other | 4 | 9% |
| Unknown | 6 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2013.
All research outputs
#5,942,633
of 22,986,950 outputs
Outputs from Biogerontology
#216
of 659 outputs
Outputs of similar age
#32,658
of 157,119 outputs
Outputs of similar age from Biogerontology
#4
of 6 outputs
Altmetric has tracked 22,986,950 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 659 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has gotten more attention than average, scoring higher than 66% of its peers.
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