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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue
|
|---|---|
| Published in |
Nature Communications, February 2014
|
| DOI | 10.1038/ncomms4365 |
| Pubmed ID | |
| Authors |
Jianxin Shi, Crystal N. Marconett, Jubao Duan, Paula L. Hyland, Peng Li, Zhaoming Wang, William Wheeler, Beiyun Zhou, Mihaela Campan, Diane S. Lee, Jing Huang, Weiyin Zhou, Tim Triche, Laufey Amundadottir, Andrew Warner, Amy Hutchinson, Po-Han Chen, Brian S. I. Chung, Angela C. Pesatori, Dario Consonni, Pier Alberto Bertazzi, Andrew W. Bergen, Mathew Freedman, Kimberly D. Siegmund, Benjamin P. Berman, Zea Borok, Nilanjan Chatterjee, Margaret A. Tucker, Neil E. Caporaso, Stephen J. Chanock, Ite A. Laird-Offringa, Maria Teresa Landi |
| Abstract |
The genetic regulation of the human epigenome is not fully appreciated. Here we describe the effects of genetic variants on the DNA methylome in human lung based on methylation-quantitative trait loci (meQTL) analyses. We report 34,304 cis- and 585 trans-meQTLs, a genetic-epigenetic interaction of surprising magnitude, including a regulatory hotspot. These findings are replicated in both breast and kidney tissues and show distinct patterns: cis-meQTLs mostly localize to CpG sites outside of genes, promoters and CpG islands (CGIs), while trans-meQTLs are over-represented in promoter CGIs. meQTL SNPs are enriched in CTCF-binding sites, DNaseI hypersensitivity regions and histone marks. Importantly, four of the five established lung cancer risk loci in European ancestry are cis-meQTLs and, in aggregate, cis-meQTLs are enriched for lung cancer risk in a genome-wide analysis of 11,587 subjects. Thus, inherited genetic variation may affect lung carcinogenesis by regulating the human methylome. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 60% |
| United Kingdom | 1 | 20% |
| Australia | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 1% |
| United States | 2 | 1% |
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 142 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 39 | 26% |
| Student > Ph. D. Student | 33 | 22% |
| Student > Bachelor | 11 | 7% |
| Student > Doctoral Student | 8 | 5% |
| Student > Postgraduate | 8 | 5% |
| Other | 25 | 17% |
| Unknown | 24 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 41 | 28% |
| Agricultural and Biological Sciences | 39 | 26% |
| Medicine and Dentistry | 18 | 12% |
| Computer Science | 6 | 4% |
| Mathematics | 4 | 3% |
| Other | 11 | 7% |
| Unknown | 29 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2017.
All research outputs
#3,175,469
of 22,747,498 outputs
Outputs from Nature Communications
#28,834
of 46,825 outputs
Outputs of similar age
#33,297
of 221,166 outputs
Outputs of similar age from Nature Communications
#267
of 502 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,825 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,166 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 502 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.