Title |
Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety
|
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Published in |
Journal of Autism and Developmental Disorders, July 2017
|
DOI | 10.1007/s10803-017-3206-1 |
Pubmed ID | |
Authors |
John D. Herrington, Brenna B. Maddox, Connor M. Kerns, Keiran Rump, Julie A. Worley, Jennifer C. Bush, Alana J. McVey, Robert T. Schultz, Judith S. Miller |
Abstract |
Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 9 | 24% |
Venezuela, Bolivarian Republic of | 4 | 11% |
Spain | 4 | 11% |
Ireland | 2 | 5% |
United States | 2 | 5% |
Mexico | 1 | 3% |
Paraguay | 1 | 3% |
Italy | 1 | 3% |
Brazil | 1 | 3% |
Other | 3 | 8% |
Unknown | 9 | 24% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 27 | 73% |
Scientists | 8 | 22% |
Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 167 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 27 | 16% |
Student > Master | 24 | 14% |
Student > Bachelor | 20 | 12% |
Researcher | 18 | 11% |
Student > Doctoral Student | 12 | 7% |
Other | 26 | 16% |
Unknown | 40 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 43 | 26% |
Neuroscience | 23 | 14% |
Medicine and Dentistry | 13 | 8% |
Agricultural and Biological Sciences | 7 | 4% |
Nursing and Health Professions | 6 | 4% |
Other | 26 | 16% |
Unknown | 49 | 29% |