| Title |
Using human artificial chromosomes to study centromere assembly and function
|
|---|---|
| Published in |
Chromosoma, July 2017
|
| DOI | 10.1007/s00412-017-0633-x |
| Pubmed ID | |
| Authors |
Oscar Molina, Natalay Kouprina, Hiroshi Masumoto, Vladimir Larionov, William C. Earnshaw |
| Abstract |
Centromeres are the site of assembly of the kinetochore, which directs chromosome segregation during cell division. Active centromeres are characterized by the presence of nucleosomes containing CENP-A and a specific chromatin environment that resembles that of active genes. Recent work using human artificial chromosomes (HAC) sheds light on the fine balance of different histone post-translational modifications and transcription that exists at centromeres for kinetochore assembly and maintenance. Here, we review the use of HAC technology to understand centromere assembly and function. We put particular emphasis on studies using the alphoid(tetO) HAC, whose centromere can be specifically modified for epigenetic engineering studies. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 25% |
| Student > Bachelor | 12 | 23% |
| Student > Ph. D. Student | 10 | 19% |
| Professor | 3 | 6% |
| Professor > Associate Professor | 3 | 6% |
| Other | 6 | 12% |
| Unknown | 5 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 58% |
| Agricultural and Biological Sciences | 11 | 21% |
| Medicine and Dentistry | 2 | 4% |
| Unspecified | 1 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 7 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2017.
All research outputs
#13,326,031
of 22,986,950 outputs
Outputs from Chromosoma
#518
of 760 outputs
Outputs of similar age
#154,467
of 313,004 outputs
Outputs of similar age from Chromosoma
#3
of 7 outputs
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