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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis
|
|---|---|
| Published in |
Cell Stem Cell, March 2014
|
| DOI | 10.1016/j.stem.2014.01.009 |
| Pubmed ID | |
| Authors |
Matilde Todaro, Miriam Gaggianesi, Veronica Catalano, Antonina Benfante, Flora Iovino, Mauro Biffoni, Tiziana Apuzzo, Isabella Sperduti, Silvia Volpe, Gianfranco Cocorullo, Gaspare Gulotta, Francesco Dieli, Ruggero De Maria, Giorgio Stassi |
| Abstract |
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required for their migration and generation of metastatic tumors. CD44v6 expression is low in primary tumors but demarcated clonogenic CR-CSC populations. Cytokines hepatocyte growth factor (HGF), osteopontin (OPN), and stromal-derived factor 1α (SDF-1), secreted from tumor associated cells, increase CD44v6 expression in CR-CSCs by activating the Wnt/β-catenin pathway, which promotes migration and metastasis. CD44v6(-) progenitor cells do not give rise to metastatic lesions but, when treated with cytokines, acquire CD44v6 expression and metastatic capacity. Importantly, phosphatidylinositol 3-kinase (PI3K) inhibition selectively killed CD44v6 CR-CSCs and reduced metastatic growth. In patient cohorts, low levels of CD44v6 predict increased probability of survival. Thus, the metastatic process in colorectal cancer is initiated by CSCs through the expression of CD44v6, which is both a functional biomarker and therapeutic target. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| France | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 1 | 14% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 432 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | <1% |
| United States | 2 | <1% |
| Germany | 1 | <1% |
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| South Africa | 1 | <1% |
| Spain | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 418 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 106 | 25% |
| Researcher | 77 | 18% |
| Student > Master | 49 | 11% |
| Student > Bachelor | 40 | 9% |
| Student > Doctoral Student | 18 | 4% |
| Other | 53 | 12% |
| Unknown | 89 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 123 | 28% |
| Agricultural and Biological Sciences | 91 | 21% |
| Medicine and Dentistry | 54 | 13% |
| Immunology and Microbiology | 14 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 3% |
| Other | 36 | 8% |
| Unknown | 103 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2023.
All research outputs
#3,542,654
of 25,374,647 outputs
Outputs from Cell Stem Cell
#1,629
of 2,823 outputs
Outputs of similar age
#34,505
of 236,361 outputs
Outputs of similar age from Cell Stem Cell
#28
of 41 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,823 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.5. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,361 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.